不同年代首次住院心境障碍患者药物应用状况分析  

Investigations on medicine usage status of first-time hospital- ized mood disorder patients in various years

作　　者：李文飞[1] 曹小梅[1] 白伟[1] 王瑞斌[1] 余家快[1] 

机构地区：[1]安徽省精神卫生防治中心,安徽合肥230022

出　　处：《临床心身疾病杂志》2012年第5期416-419,共4页Journal of Clinical Psychosomatic Diseases

摘　　要：目的探讨不同年代首次住院心境障碍患者药物应用状况。方法将1989年度、1999年度、2009年度在我院首次住院的心境障碍患者分别设为A组（77例）、B组（136例）、C组（136例），统计3组患者的药物应用状况。结果3组新型抗精神病药物、抗抑郁剂、情绪稳定剂及苯二氮茧类药物应用频率比较差异均有显著性（P〈0．05或0．01）；新型抗精神病药物、新型抗抑郁剂、苯二氮茧类药物及情绪稳定剂丙戊酸钠应用频率显著升高。结论首次住院心境障碍患者新型抗精神病药、新型抗抑郁剂及苯二氮革类药物应用频率有明显增加趋势，而情绪稳定剂中单用丙戊酸钠及丙戊酸钠联合碳酸锂治疗明显增加，临床用药状况趋向合理化。Objective To explore medicine usage status of first-time hospitalized mood disorder patients in various years. Methods Seventy-seven first-time hos- pitalized mood disorder patients selected with cluster sampling in 1989 were as-signed to group A, 136 ones in 1999 to B and 136 ones in 2009 to C, and medicine usage status of three groups added up. Results There were significant differences in used frequency of novel antipsychotics, an- tidepressants, mood stabilizers and benzodiazepines among three groups （P〈0.05 or 0.01） ; used frequen- cy of novel antipsychotics, antidepressants, mood stabilizers and benzodiazepines heightened more notably. Conclusion Used frequencies of novel antipsychotics and antidepressants as well as benzodiazepines in- crease notably, those of single sodium valproate and sodium valproate plus lithium carbonate increase nota- bly, clinical medicine usage status trends rationally.

关 键 词：心境障碍 抗精神病药物 抗抑郁剂 首次住院 情绪稳定剂 苯二氮类药物 

分 类 号：R749.4[医药卫生—神经病学与精神病学]