度洛西汀联合心理干预治疗产后抑郁症对照研究  

A control of duloxetine combined with psychological interven- tion in postpartum depression

作　　者：穆小梅 洪贵子 李小红[1] 魏长礼 牛慧明 张子明[1] 林战军 王秀梅[1] 颉瑞 侯宁[1] 庞润慧 

机构地区：[1]天水市第三人民医院,甘肃天水741000

出　　处：《临床心身疾病杂志》2012年第5期475-477,共3页Journal of Clinical Psychosomatic Diseases

摘　　要：目的探讨度洛西汀联合心理干预治疗产后抑郁症的临床疗效和安全性。方法将43例产后抑郁症患者随机分为两组，研究组22例，对照组21例，两组均晨口服度洛西汀治疗，研究组在此基础上联合心理干预治疗，观察6周。于治疗前及治疗2周、4周、6周末采用汉密顿抑郁量表评定临床疗效，副反应量表评定不良反应。结果治疗后两组汉密顿抑郁量表评分均较治疗前显著下降（P〈0．01），同期研究组均较对照组下降更显著（P〈0．05或0．01）；治疗6周末研究组显效率、有效率均高于对照组，但差异无显著性（P〉0．05）。研究组不良反应发生率为31．82％，对照组为47．62％，两组比较差异无显著性（P〉0．05）。结论度洛西汀联合心理干预治疗产后抑郁症较单用度洛西汀治疗起效更快，疗效更显著，且安全性高，依从性好。Objective To explore the efficacy and safety of duloxetine combined with psychological inter vention in the treatment of postpartum depression （PD）. Methods Forty three PD patients were randomly divided into research （n=22） and control group （n=21）, both groups took orally duloxetine in the morn- ing, research group was plus psychological intervention for 6 weeks. Efficacies were assessed with the Hamilton Depression Scale （HAMD） and adverse reactions with the Treatment Emergent Symptom Scale （TESS） before treatment and at the end of the 2nd, 4th and 6th week. Results The HAMD scores of both groups lowered more significantly after treatment compared pretreatment （P〈0.01）, so did those in re- search than in control group in the corresponding time period （P〈0.05 or 0.01） ; both obvious effective and effective rate were higher in research than in control group at the end of the 6th week, but differences were not significant （P^0.05）. The incidence of adverse reactions were respectively 31.82% in research and 47.62% in control group, which showed no significant difference （P〉0.05）. Conclusion Duloxetine combined with psychological treatment takes effect more rapidly, has more notable efficacy, higher safety and better compliance compared with single duloxetine in the treatment of postpartum depression.

关 键 词：度洛西汀 心理干预 产后抑郁症 汉密顿抑郁量表 

分 类 号：R749.053[医药卫生—神经病学与精神病学] R749.4[医药卫生—临床医学]