陕西省延安地区胃黏膜异型增生证候特征及发病因素探讨  

Research of gastric mucosal dysplasia syndrome characteristics and risk factors in Yan'an region of Shanxi

作　　者：惠建萍[1] 沈舒文[1] 刘力[1] 刘梅君[2] 

机构地区：[1]陕西中医学院临床医学院,陕西咸阳712046 [2]陕西省延安市人民医院消化内科,陕西延安716000

出　　处：《河北中医》2012年第9期1295-1296,1299,共3页Hebei Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(编号:30873266)

摘　　要：目的研究陕西省延安地区胃黏膜异型增生(Dys)中医证候特征及发病因素。方法将首诊病理诊断为Dys的患者,通过望、闻、问、切采集临床症状体征资料,录入Dys虚实关联数据库辨识系统进行辨识,属虚实关联证者,按证候结构类型进行归类,进行证候特征研究及发病原因分析,同时检测肿瘤相关物质(tumor supplied group of factors,TSGF),分析Dys虚实关联证候类型与TSGF的相关性。结果 Dys证情复杂,证候多为虚实共存,虚证主要为脾胃气虚、脾胃虚寒及胃阴不足,实证主要为肝胃气滞及瘀阻胃络,其发病主要与受寒、劳累、嗜食辛辣及烟酒等因素有关。TSGF水平的高值峰出现在寒热错杂证即湿热蕴胃并/兼脾胃虚寒和胃络瘀阻并/兼胃阴不足、脾胃虚寒中。结论 Dys的证候特点为虚实关联证,单实证仅见疾病早期或加重期,单虚证多在其稳定阶段或恢复期。Objective To study the syndrome characteristics and risk factors of gastric mucosal dysplasia in Yan＇an region of Shaanxi.Methods Gastric mucosal dysplasia patients with Xu-Shi correlation syndromes were diagnosed by endoscopy and histopathology were entered database of Xu-Shi correlation to study its traditional Chinese medicine syndrome type and distribution.Syndrome characteristics and causes were analyzed tumor supplied group of factors（TSGF） was measured.Correlation between types of Xu-Shi correlation syndrome and change of TSGF level was evaluated.Results The syndrome situation of dysplasia is complex and many of coexistence syndromes of deficiency and positive.A single positive only can be seen of early in the disease or exacerbation.A single deficiency can be seen only in its stable phase or recovery.High value peak of TSGF level appeared at cold-heat complex syndrome including： hydrotherm accumulating stomach combined with spleen-stomach deficiency-cold and stomach complex stasis resistance combined with insufficiency of spleen-YANG,deficiency cold of the spleen.Conclusion The syndrome characteristics of gastric mucosal dysplasia is Xu-Shi correlation syndrome,asthenia syndrome was deficiency of spleen-QI and stomach-QI,insufficiency of spleen-YANG,deficiency cold of the spleen and stomach yin deficiency.Sthenia syndrome was stagnation of liver-QI and stomach-QI and obstruction in the hepatic chollateral.The incidence of gastric mucosal dysplasia may be associated with chills,tiredness addicted to spicy food,alcohol,tobacco and other factors.

关 键 词：胃黏膜 证候 发病因素 

分 类 号：R573.025[医药卫生—消化系统]