恶性肿瘤中人绒毛膜促性腺激素β亚单位的研究进展  

Progress in Study on Expression of βhCG in Malignant Tumors

作　　者：赵兴会[1] 周晓光[1] 赵霞[1] 朱文秀[1] 韩世愈[1] 

机构地区：[1]哈尔滨医科大学第四临床医学院妇产科,黑龙江哈尔滨150001

出　　处：《现代生物医学进展》2012年第24期4773-4776,共4页Progress in Modern Biomedicine

摘　　要：人绒毛膜促性腺激素是一种糖蛋白激素。在妊娠期主要由胎盘合体滋养层细胞分泌产生,在非妊娠情况下,机体内含量极微。目前发现几乎所有组织,尤其是肿瘤包括乳腺癌、子宫颈癌、卵巢癌、膀胱癌等均可产生人绒毛膜促性腺激素β亚单位。人绒毛膜促性腺激素对胎盘和生殖细胞起源的滋养细胞肿瘤是一个非常敏感和特殊的肿瘤标志物。很多非滋养细胞肿瘤只产生βhCG,而这是侵袭性疾病的标志,血清中提高的βhCG水平是和肿瘤的不良预后相联系的。Human chorionic gonadotuopin （hCG）is a glycoprotein hormone. It is mainly secreted by placental syntrophohlastic cells during pregnancy. In non-pregnanay period, there is few hCG in body. At present βhCG has been found in almost all tissues espe- cially tumor tissues including mammary cancer, cervical carcinoma, ovarian carcinoma, bladder carcinoma etc. Human cborionic go- nadotropin is an extremely sensitive and specific marker for trophoblastic tumors of placental and germ cell origin. Many nontro- phoblastic tumors only produce hCGβ, This is usually a sign of aggressive disease and elevated serum levels of hCGβ which is strongly associated with poor prognosis.

关 键 词：BhCG 恶性肿瘤 

分 类 号：R730.231[医药卫生—肿瘤] R737.3[医药卫生—临床医学]