与胃癌发生相关MicroRNA的研究新进展  

The Research on the Development of Gastric Cancer-related MicroRNA

作　　者：黄胜蓝[1] 郑长黎[1] 

机构地区：[1]中南大学湘雅医学院病理系,湖南长沙410013

出　　处：《现代生物医学进展》2012年第24期4777-4779,共3页Progress in Modern Biomedicine

摘　　要：MicroRNA(微小核糖核酸;miRNA)是一类长约20～25个核苷酸的非编码的单链RNA分子。它的表达与个体发育、增殖、分化以及恶性肿瘤发生密切相关。近期研究表明microRNA具有癌基因和抑癌基因的作用。新研究发现miR-20b,miR-150,miR-106a,miR-27a,miR107,miR-21,miR-20a与胃癌的发生过程呈正相关;而Let-7microRNA,miR-218,miR-101,miR-650,miR-29,miR-34,miR-451与胃癌的发生过程呈负相关。本文就胃癌发生相关microRNA的研究新进展予以综述。MicroRNA are endogenous non-coding RNA about 20~25 nucleotide; There are close association between expres- sion of mieroRNA and biologic processes including individual development cell apoptosis, proliferation, differentiation diseases （such as malignant tumor）. Recent studies indicate that mieroRNA can function as both oneogene and anti-oneogent, miR-20b, miR-150, miR-106a, miR-27a, miR107and miR21, miR-20a have been demonstrated to be positively regulated to the development of the gastric cancer; Let-TmicroRNA, miR-218, miR-101, miR-650, miR-29, miR-34 and miR-451 have been demonstrated to be negatively regulated to the development of the gastric cancer. This article reviewed the research advancement about mieroRNA in gastric cancer.

关 键 词：MICRORNA 胃癌 癌基因 抑癌基因 肿瘤 

分 类 号：R735.2[医药卫生—肿瘤]