质子泵抑制剂在3种Ⅰ类切口清洁手术患者中使用的合理性分析  

Rationality analysis of proton pump inhibitor used in the three kinds of surgical patients after class Ⅰ incision clean surgery

作　　者：邓冲[1] 陈翔[1] 陈如大[1] 

机构地区：[1]南方医科大学附属南海医院药学科临床药学室,广东佛山528200

出　　处：《中国现代医生》2012年第22期144-145,共2页China Modern Doctor

摘　　要：目的考察质子泵抑制剂(proton pump inhibitor,PPI)在3种Ⅰ类切口清洁手术(甲状腺次全切术、乳腺肿物切除术、充填式张力疝修补术)术后应用的合理性,旨在提高我院临床合理用药的水平。方法选取2010年我院3种Ⅰ类切口清洁手术(甲状腺次全切术、乳腺肿物切除术、充填式无张力疝修补术)患者,分为实验组(术后使用PPI)351例和对照组(术后不使用抑酸药)366例,经统计分析实验组与对照组在预防术后应激性溃疡和吸入性肺炎的差别。结果实验组与对照组比较,其术后应急性溃疡和吸入性肺炎的发生率均无显著性差异(P>0.05)。结论行甲状腺次全切术、乳腺肿物切除术、充填式张力疝修补术的患者术后使用PPI预防应激性溃疡和吸入性肺炎是没有必要的,是PPI过度使用的一种表现。Objective To investigate the use of proton pump inhibitor in 3 kinds of surgical patients after class I Incision clean surgery, including thyroid subtotal resection, filled with tension-free hernia repair and breast tumor resection. It was aimed at raising the level of hospital clinical rational drug use. Methods Three kinds of class I incision clean surgery （subtotal thyroidectomy resection of the breast tumor resection, filling tension-free hernia repair） patients was divided to experimental group （administrated with PPI） of 351 cases and control group （not administrated with PPI） of 366 cases. All the data of the experimental group and control group in the prevention of postoperative emergency ulcers and aspiration pneumonia were analyzed. Results The two groups showed no significant difference （P 〉 0.05）. Conclusion It was not necessary for patients done with thyroid resection, the breast tumor resection and filling hernia repair to administrate with PPI to prevent stress ulcers and aspiration pneumonia. It was a kind of behavior of PPI excessive use.

关 键 词：质子泵抑制剂 Ⅰ类切口清洁手术 应急性溃疡 吸入性肺炎 

分 类 号：R573.1[医药卫生—消化系统]