脑膜癌病33例临床分析及治疗  

Clinical and Diagnostic Methods Analysis of Meningeal Carcinomatosis in 33 Patiants

作　　者：陈倩[1] 何俊瑛[2] 

机构地区：[1]航天中心医院,北京100049 [2]河北医科大学附属第二医院,河北石家庄050000

出　　处：《医学信息》2012年第7期106-107,共2页Journal of Medical Information

摘　　要：目的脑膜癌病（MC）33例临床分析及多种诊断方法探讨。方法对我院2009年2月-2011年8月33例诊断MC患者进行回顾性分析。结果12例经MRI增强扫描，确诊率为50．00％（6／12），33例脑脊液细胞学均见癌细胞，首次检查阳性率为87．88％（29／33），MRI增强扫描与脑脊液细胞学两种方法阳性率比较差异有显著性（P〈0．05）。结论MC以进行性难以忍受的剧烈头痛为主要症状，脑膜刺激征多阳性，其临床表现无特异性，误诊率高，脑脊液细胞学是早期诊断MC的重要手段，优于MRI增强扫描，鞘内化疗可延长患者生命。Objective To explore clinical features and diagnostic methods of 33 patients with meningeal careinomatosis Methods The clinical data of 33 patients with meningeal carcinomatosis during Feburery 2009 to August 2011 were retrospectively analyzed.Results the final diagnosis rate of cranial Gadolinium-enhanced MRI in 12 patients with MC were 50.00%.There was a high positive rate in malignant cells which were identified in all of 33 cases. The positive rate of routine cerebrospinal fluid cytologic examination for the first time were 87.88%.There was a significant difference （ P 〈 0.05） between cranial Gadolinium-enhanced MRI and cytologic examination of CSF. Conclusions The clinical manifestations of MC lacks specificity,cytological examination of CSF is a reliable earlier importannt diagnosing method for this disease.h is better than Gadolinium-enhanced MRI for the diagnosis of MC. Intrathecal chemotherapy is a effective therapy method for prolonging the life of these patients.

关 键 词：脑膜癌病 脑脊液 脑脊液细胞学 鞘内化疗 

分 类 号：R739.45[医药卫生—肿瘤]