40岁以下青年非小细胞肺癌患者的预后及其影响因素分析  

Analysis of prognostic factors of non-small cell lung cancer in patients under 40 years of age

作　　者：徐春华[1] 于力克[1] 张宇[1] 谢海燕[1] 郝可可[1] 胡韡[1] 夏宁[1] 展平[1] 

机构地区：[1]南京市胸科医院呼吸科,210029

出　　处：《中华肿瘤杂志》2012年第9期703-705,共3页Chinese Journal of Oncology

摘　　要：目的探讨40岁以下青年非小细胞肺癌（NSCLC）患者的生存状况，分析其预后影响因素。方法回顾性分析148例青年NSCLC患者的临床病理资料，采用Kaplan—Meier法和Cox回归法分析各因素对预后的影响。结果随访6～148个月，随访率为100％。全组死亡122例，生存26例。全组患者的1、3、5年生存率分别为54．7％、10．4％和5．6％，中位生存时间为14．7个月。单因素分析结果显示，KPS评分、临床分期、治疗方式和血清癌胚抗原（CEA）水平与青年NSCLC患者的预后有关（均P〈0．05）。Cox多因素分析结果显示，KPS评分、临床分期、治疗方式以及血清CEA水平均是影响青年NSCLC患者预后的独立因素（均P〈0．05）。结论KPS评分、临床分期、治疗方式以及血清CEA水平是影响青年NSCLC患者预后的独立因素。Objective To investigate the prognostic factors for non-small cell lung cancer（NSCLC） in patients under 40 years of age. Methods The clinicopathological data of 148 young patients with NSCLC were retrospectively analyzed. Kaplan-Meier and Cox regression analyses were used to analyze the relationship between prognostic factors and survival time. Results The patients were followed-up for 6-148 months, and the follow-up rate was 100%. In the whole group, 122 patients died and 26 cases were surviving. The 1-, 3- and 5-year survival rates were 54.7% , 10.4% and 5.6% , respectively. The median survival time （MST） was 14.7 months. Kaplan-Meier analysis showed that Karnofsky performance status （ KPS）, clinical stage, treatment modality and serum CEA were related with prognosis （ P 〈 0. 05 ）. Multivariate analysis indicated that KPS, clinical stage, treatment modality and serum CEA were independent prognostic factors （P 〈 0. 05 ）. Conclusions KPS, CEA, clinical stage and treatment modalities are independent prognostic factors in young NSCLC patients.

关 键 词：癌 非小细胞肺 青年 预后 比例危险度模型 

分 类 号：R734.2[医药卫生—肿瘤]