甲状腺显示胸腺样分化的癌6例临床病理分析  

Clinicopathological features of carcinoma showing thymus-like differentiation of thyroid in six cases

作　　者：梁伟[1] 马捷[1] 姜少军[1] 陆珍凤[1] 周晓军[1] 

机构地区：[1]南京军区南京总医院病理科,南京210002

出　　处：《临床与实验病理学杂志》2012年第9期1002-1005,共4页Chinese Journal of Clinical and Experimental Pathology

摘　　要：目的探讨甲状腺显示胸腺样分化的癌(carcinoma showing thymus-like differentiation,CASTLE)临床病理学特点及其鉴别诊断。方法对6例CASTLE进行组织形态学观察、免疫组化标记及电镜观察。结果镜下肿瘤组织常呈巢状分布伴较多淋巴细胞反应,癌细胞呈多边形或梭形,核卵圆形,呈空泡状,有清楚的小核仁,核分裂象少。免疫组化示癌细胞表达CD5及CD117等。电镜下癌细胞含较多的线粒体及张力原纤维,细胞间桥粒丰富。结论甲状腺CASTLE的诊断依靠形态学及免疫组化标记,超微病理结构特征有助于与其他甲状腺恶性肿瘤相鉴别。Purpose To study clinicopathological features and differential diagnosis of carcinoma showing thymus-like differentiation （CASTLE）. Methods Six cases of CASTLE were studied by light microscopy, immunohistochemistry and electron microscopy. Re- suits Microscopically, the tumor cells arranged in nests with various degree of lymphocytic infiltration. The tumor ceils were polygonal to spindle in shape with oval vesicular nucleus and small distinct nucleoli, but mitoses were rare. Immunohistochemically, the tumor cells characteristically stained positive for CD5 and CD117. Uhrastructurally, the tumor cells contained many mitochondria and tonofi- brils in the cytoplasm, and desmosomes were easily found between the tumor cells. Conclusions The diagnosis of CASTLE depends on morphology and immunohistochemical examination. Ultrastructural features are helpful for the differential diagnosis of CASTLE from other tumors of the thyroid.

关 键 词：甲状腺肿瘤 显示胸腺样分化的癌 免疫表型 超微病理 

分 类 号：R738.6[医药卫生—肿瘤]