膀胱尿路上皮癌组织中p120ctn和VEGF蛋白的表达及意义  

Expressions and clinical significance of p120ctn and VEGF in urothelial carcinoma of bladder

作　　者：梁凯[1] 卢德祥[1] 郑言清[1] 林思宇[1] 

机构地区：[1]黑龙江省医院南岗院区泌尿外科,黑龙江哈尔滨150001

出　　处：《中国校医》2012年第9期703-704,共2页Chinese Journal of School Doctor

摘　　要：目的观察链蛋白p120(p120ctn)、血管内皮生长因子(VEGF)在膀胱尿路上皮癌组织中的表达变化,并探讨其意义。方法采用免疫组化(S-P)法检测100例膀胱尿路上皮癌(膀胱癌组)及40例正常膀胱黏膜(正常组)中的p120ctn、VEGF蛋白表达情况,并分析两者间及蛋白表达与膀胱尿路上皮癌临床分期、病理分级的关系。结果膀胱癌组和正常组p120ctn阳性表达率分别为54%和87.5%,差异有统计学意义(P<0.05);VEGF阳性表达率分别为93%和42.5%,差异有统计学意义(P<0.05)。在膀胱癌组织中p120ctn和VEGF蛋白的表达水平和肿瘤的病理分型、临床分期呈正相关趋势。结论 p120ctn和VEGF的表达水平在膀胱癌的发生发展过程中发生变化并与肿瘤的病理分级和临床分期相关,可作为判断膀胱癌生物学特征的重要指标。Objective To detect the expressions of p120ctn and VEGF and discuss their clinical significance in urothelial carcinoma of the bladder. Methods The imrnunohistochemistry method was used to examine the expressions of pl20ctn and VEGF in 100 urothelial carcinoma of bladder tissues （a bladder cancer group） and 40 normal bladder mucosa tissues （a normal group）. Results The positive expression rates of p120ctn in the bladder cancer group and normal group were 54 % and 87.5 % respectively （ P 〈 0.05） ; the positive expression rates of VEGF in the bladder cancer group and normal group were 93 % and 42.5 % respectively （P 〈 0.05）. In urothelial carcinoma of the bladder tissues, the positive expression levels of pl20ctn and VEGF were positive correlated with the pathological grade and clinical stage. Conclusions The expression levels of pl20ctn and VEGF might change during the development and progression of bladder cancer and were associated with the pathological grade and clinical stage, which could be used as important indicators to judge the biological characteristics of bladder cancer.

关 键 词：膀胱肿瘤 连接素 血管内皮生长因子A 

分 类 号：R737.14[医药卫生—肿瘤]