疣状胃炎胃黏膜T淋巴细胞亚群变化及其临床意义  

Alteration and clinical significance of gastric mucosal T lymphocytes subgroup in verrucous gastritis

作　　者：郭春丽[1] 丁西平[1] 胡闻[2] 虞文永[1] 王巧民[1] 

机构地区：[1]安徽医科大学附属省立医院消化内科,合肥230001 [2]安徽医科大学附属省立医院病理科,合肥230001

出　　处：《安徽医科大学学报》2012年第10期1229-1233,共5页Acta Universitatis Medicinalis Anhui

摘　　要：目的初步检测疣状胃炎胃黏膜CD3+、CD4+、CD8+T细胞的变化,并观察疣状胃炎胃黏膜超微结构改变。方法采用免疫组化法检测疣状胃炎和慢性浅表性胃炎胃黏膜CD3+、CD4+、CD8+T细胞变化,透射电子显微镜观察疣状胃炎胃黏膜超微结构;14C-呼气试验确定是否有幽门螺杆菌(HP)感染。结果疣状胃炎较慢性浅表性胃炎CD8+T细胞明显降低,CD4+/CD8+比值明显升高(P<0.05);疣状胃炎HP阳性组较HP阴性组CD3+、CD4+、CD8+T细胞明显升高(P<0.01,P<0.05);疣状胃炎胃黏膜腺上皮细胞结构不同程度破坏,线粒体出现病毒颗粒。结论疣状胃炎的发生可能与免疫功能紊乱有关,HP、病毒感染可能是导致免疫紊乱的病因。Objective To investigate the change of gastric mucosal CD3＋, CD4＋, CD8＋ T lymphocytes and ultrastructures of verrucous gastric mucosa. Methods Gastric mucosal CD3＋ , CD4＋ , CDS＋ T lymphocytes in both verrucous and chronic superficial gastritis were analyzed by immunohistochemistry, ultrastructures of verrucous gastric mucosa were observed by transmission electron microscope and 14^C-urea breath test was used to determine whether patients were infected with helieobacter pylori（HP）. Results The number of CD8＋ T lymphocytes decreased significantly and CD4＋/CD8＋ ratio significantly increased in verrueous gastritis as compared with chronic superficial gastritis （P 〈 0. 05 ）. The number of CD3 ＋ , CD4＋ , CD8＋ T lymphocytes significantly increased in verrucous gastritis of HP positive as compared with HP negative （ P 〈 0. 01, P 〈 0. 05 ）. Structures of epithelial cells in verrucous gastritic mucosa were destructed to varying degrees and virosomes were observed in mitochondria. Conclusion The results of this study indicate that the patients with verrucous gastritis may be associated with the immune system dysfunction which may result from both HP and virus infection.

关 键 词：疣状胃炎 慢性浅表性胃炎 T细胞亚群 免疫 

分 类 号：R573.31[医药卫生—消化系统] R392.11[医药卫生—内科学]