雌激素受体β在成年C57小鼠脑内的表达与性别差异  

Expression of estrogen receptor β in brain of adult C57 mouse and its gender differences

作　　者：周红利[1,2] 邓其跃[3] 苏炳银[1,2] 张吉强[3] 

机构地区：[1]成都医学院人体解剖学与组织学胚胎学教研室 [2]成都医学院发育与再生四川省重点实验室,成都610083 [3]成都医学院第三军医大学神经生物学教研室,重庆市神经生物学重点实验室,重庆400038

出　　处：《解剖学杂志》2012年第4期423-426,435,共5页Chinese Journal of Anatomy

基　　金：国家自然科学基金（81171035）;重庆市自然基金（CSTS,2008BB5110）

摘　　要：目的：观察雌激素受体β（ER-β）在成年小鼠脑内的性别差异。方法：成年C57小鼠用硫酸镍铵增强显色的免疫组织化学SP法。结果：ER-β在脑内有广泛的分布，ER-B免疫阳性产物主要表达于细胞核，但在个别脑区也可在胞质甚至突起内检测到。ER-β的表达具有一定的性别差异，在部分脑区ER-β的表达表现为雄性强于雌性，而在另一些脑区则相反，并且该受体的脑核团定位方面表现出某些性别差异。结论：在不同性别的动物同一核团，ER_β口发挥的调节作用可能不一样，这可能是造成脑的性别差异的原因之一。Objective： To study the localization and sex differences of estrogen receptor β （ER-β） in the brain of adult female and male mice. Methods： Nickel-intensified immunohistochemistry was used. Results： ER-β immunopositive materials were widely distributed in the brain of both female and male mice. They were predominantly localized in the cell nuclei in most of the brain regions, but also detectable in some limited regions. Some sex-differences of ER-~ immunoreactivities were noticed, with significant male-predominance in some nuclei but female-dominance in other nuclei. Conclusion： The ER-β extensive distribution of ER-β in the brain indicates its multiple functional roles in the brain. The sex-specific distribution pattern may be one of the mechanisms underlying gender-specific differences of brain structure and function such as learning and memory.

关 键 词：雌激素受体Β 脑 性别差异 免疫组织化学 小鼠 

分 类 号：R737.9[医药卫生—肿瘤]