EZH2和P130在唾液腺腺样囊性癌中的表达及意义  

Expression and Significance of EZH2 and P130 in Salivary Adenoid Cystic Carcinoma

作　　者：迟艳侠[1] 李德超[1] 南晓利[1] 杜欣娜[1] 刘海花[1] 刘凤华[2] 张杰[2] 

机构地区：[1]佳木斯大学附属口腔医院,黑龙江佳木斯154002 [2]佳木斯大学药学院

出　　处：《口腔医学研究》2012年第9期894-896,共3页Journal of Oral Science Research

基　　金：黑龙江省教育厅科研项目(编号:11551507)

摘　　要：目的:研究EZH2和P130在唾液腺腺样囊性癌中的表达及意义。方法:应用SP免疫组化法检测EZH2、P130蛋白在唾液腺腺样囊性癌中的表达。结果:EZH2在腺样囊性癌中的阳性表达率为67.86%,在正常腮腺组织中均为阴性表达,组间比较差异具有统计学意义(P<0.05)。P130在腺样囊性癌中的阳性表达率为25.00%,在正常腮腺组织中的阳性表达率为90.0%,组间比较差异具有统计学意义(P<0.05)。EZH2、P130在腺样囊性癌中的表达呈负相关。结论:EZH2与P130的异常表达可能在唾液腺腺样囊性癌的发生与发展过程中起重要作用。Objective： To study the expression and significance of EZH2 and P130 in salivary adenoid cystic carcinoma. Methods： The expressions of EZH2 and P130 protein were detected by immunohistochemical method（SP） in salivary adenoid cystic carcinoma. Results： EZH2 protein expressions in salivary adenoid cystic carcinoma and parotid gland were respectively 67.86% and 0. 00%, which had a significant difference between groups（P〈0.05）. PI30 protein expressions in salivary adenoid cystic carcinoma and parotid gland were respectively 25.00% and 90.0%, which had asignificant difference between groups（P〈0.05）, and two proteins were negatively correlated. Conclusion： Abnormal expression of EZH2 and P130 in salivary adenoid cystic carcinoma occurrence and development process plays an important role.

关 键 词：EZH2 P130 免疫组化 唾液腺腺样囊性癌 

分 类 号：R739.8[医药卫生—肿瘤]