青年近视患者神经纤维层厚度的临床研究  

The clinical research of retinal nerve fiber layer thickness in young myopic patients before the refractive surgery

作　　者：刘林[1] 鲍慧婧[2] 杨丽萍[1] 黄辉[2] 陈少彤[2] 邹俊[2] 

机构地区：[1]苏州大学,215000 [2]上海交通大学附属第六人民医院眼科,200233

出　　处：《中华眼视光学与视觉科学杂志》2012年第9期546-550,共5页Chinese Journal Of Optometry Ophthalmology And Visual Science

摘　　要：目的探讨青年近视患者的神经纤维层（RNFL）厚度分布特性及其影响因素。方法横断面研究。选取准分子激光角膜屈光手术前的青年近视患者162例（162眼），平均年龄（27．0±4．6）岁，等效球镜度-0．75～11．00D，平均（-4．98±2．64）D。其中，低度近视组54例，平均等效球镜度为（-2．27±0．64）D；中度近视组55例，平均等效球镜度为（-4．54±0．79）D；高度组53例，平均等效球镜度为（-8．19±1．51）D。采用光学相干断层扫描（OCT）仪检查视盘周围神经纤维层厚度，用偏相关分析RNFL厚度与患者年龄、性别、等效球镜度、眼轴、角膜中央厚度及角膜曲率的相关性。结果本组入选患者视盘周围平均RNFL厚度：全周为（103．6±9．5）um，上方为（128．7±16．8）um，鼻侧为（67．8±16．5）um，下方为（125．9±17．2）um，颞侧为（91．9±16．9）um。各RNFL厚度参数与年龄、性别、角膜曲率、中央角膜厚度无相关性，全周、上方、鼻侧、下方的平均RNFL厚度与眼轴呈负相关（r=-0．379、-0．297、-0．180、-0．291，P〈0．05），颞侧的平均RNFL厚度则与眼轴无相关性，鼻侧、下方的平均RNFL厚度与等效球镜度呈负相关（r=-0．233、～0．163，P〈0．05），颞侧平均RNFL厚度与等效球镜度则呈正相关（r=0．159，P〈0．05）。结论青年近视患者视盘周围平均RNFL厚度上方〉下方〉颞侧〉鼻侧，全周、鼻侧、上方、下方平均RNFL厚度随眼轴的增长而变薄．下方和鼻侧RNFL厚度随等效球镜度增加而变薄，颞侧平均RNFL厚度随着等效球镜度增加而增厚。Objective To evaluate the topographic profile and influential factors of peripapillary retinal nerve fiber layer （RNFL） thickness in young myopia. Methods It was a cross-sectional study. One hundred and sixty-two eyes of 162 consecutive refractive surgery candidates were included in this study. The mean age of the subjects was 27.0±4.6 years old, the average spherical equivalent （SE） was -4.98±2.64 D with a range of -0.75 D to -11.00 D, of 54 eyes were low myopia with the mean SE was -2.27±0.64 D, 55 eyes were moderate myopia with the average SE was -4.54±0.79 D, 53 eyes were high myopia with the mean SE was -8.19±1.51 D. All subjects underwent ophthalmic examination and the imaging with the Stratus optical coherence tomography （Stratus OCT）. Data were analyzed using a partial correlation. Results The global RNFL thickness was 103.6±9.5 um, the RNFL thickness of the superior quadrant was 128.7±16.8 um, the RNFL thickness of the nasal quadrant was 67.8±16.5 um, the RNFL thickness of the inferior quadrant was 125.9±17.2 um, the RNFL thickness of the temporal quadrant was 91.9±16.9 um. No statistically significant associations between the parameters of RNFL thickness and age, gender, corneal curvature, central corneal thickness （CCT）, negative correlation between the axial length and RNFL thickness of the global, superior quadrant, the nasal quadrant, the inferior quadrant （r=-0.379, -0.297, -0.180, -0.291, All P value 〈0.05）, while no statistically significant associations between the RNFL thickness of temporal and the axial length. The partial correlation coefficient between the RNFL thickness of the superior quadrant, the nasal quadrant, the inferior quadrant, the temporal quadrant and SE was r=0.003 （P=0.968）, r=-0.233 （P=0.003）, r=-0.163 （P=0.039）, r=-0.159 （P=0.045）, respectively. Conclusion The topographic profile of peripapillary RNFL thickness is the superior quadrant 〉the inferior quadrant 〉the temporal quadrant 〉the nasal quadrant in these young myopi

关 键 词：近视:神经纤维层 体层摄影术 光学相干 

分 类 号：R778.11[医药卫生—眼科]