Syncytin和GCMa在特发性胎儿生长受限胎盘中的表达  

Expression of syncytin and glial cells missing in idiopathic fetal growth restriction placenta

作　　者：韩笑[1] 崔世红[1] 张婷[1] 张林东[1] 程国梅[1] 赵岚岚[1] 

机构地区：[1]郑州大学第三附属医院妇产科,郑州450052

出　　处：《第三军医大学学报》2012年第19期1949-1952,共4页Journal of Third Military Medical University

基　　金：河南省教育厅科技攻关项目(2010A320021)~~

摘　　要：目的探讨Syncytin及glial cells missing(GCMa)在特发性胎儿生长受限(idiopathic fetal growth restriction,IFGR)患者胎盘组织中的表达及意义。方法选取剖宫产分娩的IFGR孕妇32例为研究组,同期因社会因素剖宫产分娩的健康足月孕妇30例作为健康对照组。采用免疫组化S-P法和逆转录聚合酶链反应(RT-PCR)检测2组胎盘组织中Syncytin和GCMa的表达。结果免疫组化及RT-PCR结果均显示Syncytin和GCMa在研究组胎盘组织中表达水平低于健康对照组,差异均具有显著统计学意义(P<0.01)。Syncytin及GCMa在研究组胎盘组织中表达均降低,两者呈正相关(r=0.537,P<0.05)。结论 Syncytin与GCMa在IFGR胎盘组织中均低表达,提示可能在该疾病的发生、发展过程中起重要作用。Objective To study the expression of syncytin and glial cells missing （GCMa） in idiopathic fetal growth restriction （IFGR） placenta. Methods Thirty-two pregnant women who underwent cesarean delivery due to IFGR placenta served as an experimental group and 30 normal full-term pregnant women who underwent cesarean delivery due to social factors served as a control group in this study. Expre- ssions of syncytin and GCMa in IFGR placenta tissue samples from two groups were detected by immunohisto- chemistry （IHC） and RT-PCR, respectively. Results IHC and RT-PCR showed that the expression levels of syncytin and GCMa were significantly lower in experimental group than in control group （ P 〈 0.01 ）. The low expression levels of syncytin and GCMa in experimental group were positively correlated with each other （r = 0.537 ,P 〈0.05）. Conclusion The syncytin and GCMa expressions are down-regulated in IFGR placenta tissue, indicating that they play an important role in the occurrence and progress of IFGR placenta.

关 键 词：特发性胎儿生长受限 合体滋养细胞 SYNCYTIN GCMa 

分 类 号：R394.3[医药卫生—医学遗传学] R446.8[医药卫生—基础医学]