高效免疫蛋粉i26肠内免疫营养对胃癌患者术后化疗免疫及营养支持效果的影响  

Effect of enteral immunonutrition with hyperimmune egg powder(i26) on immune and nutritional status in gastric cancer patients during postoperative chemotherapy

作　　者：邱小文[1] 肖桂珍[1] 刘慧[1] 

机构地区：[1]广州军区广州总医院营养科,广东广州510010

出　　处：《安徽医药》2012年第9期1312-1314,共3页Anhui Medical and Pharmaceutical Journal

摘　　要：目的探讨高效免疫蛋粉i26肠内免疫营养对胃癌患者术后化疗的免疫及营养支持效果。方法 46例进展期胃癌根治术后需行辅助化疗患者,随机分为两组,肠内免疫营养组(EIN组)和普通肠内营养组(TEN组)各23例,均于术后2周开始辅助化疗,化疗期间,TEN组予普通整蛋白膳食,EIN组在TEN组基础上,予高效免疫蛋粉i26。化疗前1 d和化疗结束后第14天,检测体重、淋巴细胞亚群(CD3、CD4、CD8、CD4/CD8)、自然杀伤(NK)细胞活性、白蛋白、前白蛋白及观察化疗期间并发症。结果两组患者化疗前后各项营养指标比较,差异无显著性。但化疗过程中两组免疫指标均进一步下降,EIN组免疫指标下降程度低于TEN组;第3次化疗时,EIN组IgGI、gAI、gM、CD4、CD8、CD4/CD8值与TEN组的比较差异出现显著性,直到化疗结束。两组患者并发症发生率差别无显著性。结论高效免疫蛋粉i26肠内免疫营养能更加有效地改善胃癌患者术后的免疫功能。Objective To explore the effect of hyperimmune egg powder （i26） on immune and nutritional status during postoperative chemotherapy in patients with gastric cancer. Methods Forty-six cases with advanced gastric cancer ,who needed adjuvant chemotherapy after radical gastrectomy, were divided into 2 groups randomly, enteral immunonutrition group （ EIN group, n = 23 ） and traditional enteral nutrition group （ TEN group, n = 23 ）. Adjuvant ehemotherapies were undertaken 2 weeks after surgery. During each chemotherapy, patients in TEN group were given normal homogenate diet, and for EIN group, i26 were added in the normal diet. Body weight, blood lymphocyte subsets （CD3, CD4, CD8, CD4/CD8）, natural killer （NK） cell activity, albumin, prealbumin were examined before ld and 14 d after chemotherapy. The complications were also observed during the period. Results Before and after chemotherapy, nutritional indicators in two groups had no statistical differences. The immune parameters in both groups decreased during the chemotherapy while those in TEN lowered more quickly than those in EIN group. From the 3rd chemotherapy to the end of chemotherapy, the differences of IgG, IgA, IgM, CD4, CD8, CD4/CD8 between EIN and TEN had statistical Significance. The complication incidences in two groups were similar. Conclusion Using enteral immunonutrition with i26 during postoperative chemotherapy can more effectively improve the immune status of patients with gastric cancer.

关 键 词：i26 高效免疫蛋粉 免疫 胃癌 肠内营养 化疗 

分 类 号：R735.2[医药卫生—肿瘤]