外周血microRNA作为肿瘤标志物的研究进展  

Research Progress of MicroRNA as a Tumor Marker in Peripheral Blood

作　　者：陈荣[1] 刘光辉[1] 周总光[1] 

机构地区：[1]四川大学华西医院胃肠外科中心,四川成都610041

出　　处：《中国普外基础与临床杂志》2012年第9期1020-1023,共4页Chinese Journal of Bases and Clinics In General Surgery

基　　金：教育部博士点基金(项目编号:20080610058)~~

摘　　要：目的总结外周血小分子RNA(microRNA,miRNA)作为肿瘤标志物的研究进展。方法复习相关文献,就近年来国内外关于外周血miRNA作为肿瘤标志物的研究进展进行综述。结果 miRNA的表达存在广泛性、稳定性及特异性,并与多种疾病的发生和发展相关联。结论外周血miRNA在未来肿瘤及其他疾病的临床诊断、治疗和预后中将展示出广阔的应用前景。Objective To summarize the research progress of microRNA （miRNA） as a tumor marker in peripheral blood. Methods The domestic and international published literatures about circulating miRNA as a tumor marker in recent years were reviewed. Results The miRNA expression has universality, stability and specificity, and it is related to the occurrence and development of viarous diseases. Conclusion Circulating miRNA shows a broad application prospect in clinical diagnosis, treatment, and prognosis of tumor and other diseases.

关 键 词：小分子RNA 肿瘤标志物 诊断 治疗 

分 类 号：R730.4[医药卫生—肿瘤]