Faecal pyruvate kinase isoenzyme type M2 for colorectal cancer screening:A meta-analysis  

作　　者：Carolin Tonus Markus Sellinger Konrad Koss Gero Neupert 

机构地区：[1]Asklepios Hospital North,General and Visceral Surgery,22417 Hamburg,Germany [2]Medical Practice for Gastroenterology Lusanum,67061 Ludwigshafen,Germany [3]Department of Gastroenterology,Macclesfield District General Hospital,Macclesfield,Cheshire SK10 3BL,United Kingdom

出　　处：《World Journal of Gastroenterology》2012年第30期4004-4011,共8页世界胃肠病学杂志（英文版）

摘　　要：AIM:To present a critical discussion of the efficacy of the faecal pyruvate kinase isoenzyme type M2(faecal M2-PK) test for colorectal cancer(CRC) screening based on the currently available studies.METHODS:A literature search in PubMed and Embase was conducted using the following search terms:fecal Tumor M2-PK,faecal Tumour M2-PK,fecal M2-PK,faecal M2-PK,fecal pyruvate kinase,faecal pyruvate kinase,pyruvate kinase stool and M2-PK stool.RESULTS:Stool samples from 704 patients with CRC and from 11 412 healthy subjects have been investigated for faecal M2-PK concentrations in seventeen independent studies.The mean faecal M2-PK sensitivity was 80.3%;the specificity was 95.2%.Four studies compared faecal M2-PK head-to-head with guaiacbased faecal occult blood test(gFOBT).Faecal M2PK demonstrated a sensitivity of 81.1%,whereas the gFOBT detected only 36.9% of the CRCs.Eight independent studies investigated the sensitivity of faecal M2-PK for adenoma(n = 554),with the following sensitivities:adenoma < 1 cm in diameter:25%;adenoma > 1 cm:44%;adenoma of unspecified diameter:51%.In a direct comparison with gFOBT of adenoma > 1 cm in diameter,47% tested positive with the faecal M2-PK test,whereas the gFOBT detected only 27%.CONCLUSION:We recommend faecal M2-PK as a routine test for CRC screening.Faecal M2-PK closes a gap in clinical practice because it detects bleeding and nonbleeding tumors and adenoma with high sensitivity and specificity.AIM：To present a critical discussion of the efficacy of the faecal pyruvate kinase isoenzyme type M2（faecal M2-PK） test for colorectal cancer（CRC） screening based on the currently available studies.METHODS：A literature search in PubMed and Embase was conducted using the following search terms：fecal Tumor M2-PK,faecal Tumour M2-PK,fecal M2-PK,faecal M2-PK,fecal pyruvate kinase,faecal pyruvate kinase,pyruvate kinase stool and M2-PK stool.RESULTS：Stool samples from 704 patients with CRC and from 11 412 healthy subjects have been investigated for faecal M2-PK concentrations in seventeen independent studies.The mean faecal M2-PK sensitivity was 80.3%;the specificity was 95.2%.Four studies compared faecal M2-PK head-to-head with guaiacbased faecal occult blood test（gFOBT）.Faecal M2PK demonstrated a sensitivity of 81.1%,whereas the gFOBT detected only 36.9% of the CRCs.Eight independent studies investigated the sensitivity of faecal M2-PK for adenoma（n = 554）,with the following sensitivities：adenoma 〈 1 cm in diameter：25%;adenoma 〉 1 cm：44%;adenoma of unspecified diameter：51%.In a direct comparison with gFOBT of adenoma 〉 1 cm in diameter,47% tested positive with the faecal M2-PK test,whereas the gFOBT detected only 27%.CONCLUSION：We recommend faecal M2-PK as a routine test for CRC screening.Faecal M2-PK closes a gap in clinical practice because it detects bleeding and nonbleeding tumors and adenoma with high sensitivity and specificity.

关 键 词：Faecal pyruvate kinase isoenzyme type M2 Colorectal cancer screening Colorectal cancer Stool Faecal occult blood Adenoma Polyps 

分 类 号：R735.34[医药卫生—肿瘤]