NSCLC合并肺不张行三维适形放射治疗时PET、MRI与CT靶区勾画的对比研究  

Comparative study of impact of PET,MRI and CT on delineation of target volumes with 3D-CRT for non-small-cell lung cancer patients with atelectasis

作　　者：任育江[1] 王阁[1] 胡南[1] 余娴[1] 马俊刚[1] 刘岩海[1] 杨镇洲[1] 

机构地区：[1]第三军医大学大坪医院野战外科研究所肿瘤中心,重庆400042

出　　处：《重庆医学》2012年第27期2824-2826,共3页Chongqing medicine

摘　　要：目的探讨正电子放射经中轴断层摄影(PET)、MRI与CT对合并肺不张的非小细胞肺癌(NSCLC)行三维适形放疗时病变靶区勾画的准确性。方法对23例经病理组织学证实为NSCLC且其影像学检查伴有不同程度肺不张者,先后行胸部增强CT扫描、胸部MRI增强扫描、胸部PET-CT检查,根据扫描结果勾画原发病灶范围,分别为大体肿瘤靶区(GTV)CT、GTVMRI和GTVPET-CT,计算出GTV的体积并进行比较。结果 23例患者平均GTVPET-CT为(115.29±15.47)cm3、GTVMRI为(120.72±16.54)cm3、GTVCT为(135.21±17.34)cm3,GTVCT与GTVMRI比较,差异有统计学意义(F=6.748,P<0.01);GTVCT与GTVPET-CT比较,差异有统计学意义(F=5.596,P<0.01);GTVMRI与GTVPET-CT比较,差异无统计学意义(F=3.068,P>0.05)。结论在确定肺不张与局部病变相互关系方面PET与MRI具有较高临床价值,并由此提高了靶区定位的精确性,能更好避免对周围正常组织的损伤。Objective To investigate the accuracy of PET,MRI and CT on the delineation of target volumes of non-small-cell lung cancer（NSCLC） patients with atelectasis undergoing 3D-CRT. Methods 23 NSCLC patients with atelectasis were performed the CT enhancement scan, MRI enhancement scan and PET-CT enhancement scan. GTVCT ,GTVMRI and GTVpET-CT were delineated and the volumes were calculated for comparison. Results GTVcT ,GTVMRI and GTVPET-CT had some difference for all the patients. The average of GTVCT ,GTVMRI and GTVPET-CT were（135.21±17.34）cm^3 ,（120. 72±16. 54）cm3 and（11S. 29±15.47）cm^3 respectively. There was significant difference between GTVCT and GTVpETCT （F= 5. 596, P〈0.01）. There was no significant difference between GTVPET CT and GTVMRI （F= 3. 068,P〉0.05）. Conclusion PETCT and MRI can he utilized for evaluating the relationship of local lesion and atelectasis, which will be helpful for accurate target volume definition and bring less radiation damage to peripher al normal tissues.

关 键 词：癌 非小细胞肺 肺不张 正电子发射断层显像术 磁共振成像 计算机断层扫描 

分 类 号：R734.2[医药卫生—肿瘤]