自噬在肿瘤中的双重作用  

Dual Role of Autophagy in Cancer

作　　者：张伟然[1] 张斌[1] 曹旭晨[1] 

机构地区：[1]天津医科大学附属肿瘤医院乳腺一科,乳腺癌防治教育部重点实验室,天津市肿瘤防治重点实验室,天津市300060

出　　处：《中国肿瘤临床》2012年第18期1390-1392,共3页Chinese Journal of Clinical Oncology

基　　金：国家自然科学基金(编号:81001186);天津市自然科学基金(编号:10JCYBJC14100)资助~~

摘　　要：自噬是一种溶酶体降解途径,通过对细胞内变性蛋白或受损细胞器进行降解,以维持细胞内物质循环及代谢调节的稳定。自噬是一把双刃剑,在肿瘤微环境中,自噬既能在不利环境中提高肿瘤细胞对应激的耐受能力,维持其生存,又能在肿瘤发展的不同阶段抑制其产生和转移,甚至成为某些凋亡缺陷肿瘤细胞的死亡途径。此外,自噬的双重作用还表现在癌症治疗过程中。因此,深入探讨自噬在肿瘤中的双重作用有助于为肿瘤防治提供新思路。Abstract Autophagy, which is a homeostatic mechanism for intracellular recycling and metabolic regulation, has emerged as a lysosomal degradation pathway for the breakdown of intracellular proteins and organelles. Autophagy has dual roles in cancer, namely, as a mechanism for cell survival that confers stress tolerance and as a tumor suppressor by preventing tumorigenesis and metastasis or even as a death pathway for some cancer cells with apoptotic defects. In addition, the dual role of autophagy is also involved in cancer treatment. This study further discusses the dynamic nature of autophagy and provide new approaches for cancer therapy.

关 键 词：自噬 肿瘤 治疗 

分 类 号：R730.2[医药卫生—肿瘤]