长期服用抗精神病药物对脑电图的影响及相关因素分析  

ANALYSIS OF THE ELECTROENCEPHALOGRAM CHANFES AND RELATED FACTORS IN PATIENTS WITH ANTIPSYCHOTICS FOR LONG TIME

作　　者：朱慧[1] 朱敏[1] 肖正军[1] 

机构地区：[1]扬州大学医学院附属扬州五台山医院,225003

出　　处：《现代电生理学杂志》2012年第3期131-133,共3页Journal of Modern Electrophysiology

摘　　要：目的:了解长期服用抗精神病药物对脑电图的影响并分析其相关因素。方法:对196例长期住院的精神疾病患者服用抗精神病药后脑电图变化进行分析,分别按年龄、服药时间、服用药物种类进行比较,并对多个危险因素进行相关回归分析。结果:196例受检患者中118例(60.2%)患者脑电图异常,其中以轻度异常最常见。年龄大的患者与服用氯氮平的患者出现脑电图异常的比率最高。服用药物种类与年龄作为与脑电图异常相关的变量进入了Logistic回归模型。结论:长期服用抗精神病药物引起脑电图异常较常见,尤其是服用氯氮平、年龄大的患者。Objective： To analysis the electroencephalogram （ EEG ） changes and its related factors in patients with antipsychotics for long time. Methods： The change of 196 inpatients with antipsychotics were analyzed and the factors of age, medication time and kinds of antipsychotics were compared and regressiong analysis of multivariable dangerous fcetors was done. Results： In 196 patienes, EEG of 118 （60.2%） patients were abnormal, in which, mild abnormalities of EEG was the most common. The patients with old age and clozapine have high abnomaml rate. Logistic regression analysis showed that the variable of age and kinds of antipsychotics were entered the predictive equation. Conclusion： The EEG changes were common in patients with antipsychotics especially for those patients with old age and clozapine.

关 键 词：抗精神病药物 脑电图 

分 类 号：R749.3[医药卫生—神经病学与精神病学]