新型纳米抗菌无机填料的合成及其抗菌性能的初步研究  

Study on synthesis on a novel nano-antibacterial inorganic filler and its antibacterial property

作　　者：吴峻岭[1,2] 金婵媛[1,2] 聂晓萌[1,2] 周凯运[3] 周传建[3] 

机构地区：[1]山东大学口腔医院口腔修复科 [2]山东省口腔生物医学重点实验室,济南250012 [3]山东大学材料科学与工程学院高分子材料研究所,济南250061

出　　处：《华西口腔医学杂志》2012年第5期526-529,534,共5页West China Journal of Stomatology

基　　金：山东省优秀中青年科学家科研奖励基金资助项目(BS2-010YY020);山东大学自主创新基金资助自由探索项目(2010TS079)

摘　　要：目的合成新型的纳米抗菌无机填料,为赋予牙科复合树脂抗菌性能提供新的思路。方法通过有机合成的方法,首先合成了季铵盐:N,N,N-三甲基-3-(三甲氧基硅基)丙基-1-碘化铵,然后再将其枝接到纳米二氧化硅颗粒表面,得到新型纳米抗菌无机填料季铵盐修饰纳米二氧化硅,并对合成产物结构进行表征。然后以变异链球菌为对象,研究季铵盐修饰纳米二氧化硅的抗菌性能。结果红外光谱分析表明,季铵盐成功地枝接到了纳米二氧化硅颗粒表面。与对照组相比,新型纳米抗菌无机填料对变异链球菌具有较强的杀菌作用(P<0.01)。结论季铵盐修饰纳米二氧化硅颗粒具有较好的抗菌性能,可以用来提高牙用复合树脂的抗菌性。Objective To synthesize a novel nano-antibacterial inorganic filler and provide a new way to give dental composite resin antibacterial property. Methods Quaternary ammonium iodide N,N,N-trimethyl-3-（trimethoxysilyD propan-l-aminium iodide were organically synthesized firstly and then the N,N,N-trimethyl-3-（trimethoxysilyD propan- 1-aminium iodide was grafted to the nano-silica particle to synthesize the antibacterial inorganic fillers nano-silica particle grafted with quaternary ammonium salt. All the products were analyzed and identified by infrared spectrum analysis. Then Streptococcus mutans were chosen as experimental object to analysis the antibacterial property of nano- antibacterial inorganic filler. Results Quaternary ammonium salt was grafted to the surface of nano-silica particles successfully by infrared spectrum analysis. Compared with the control group, the nano-silica particle grafted with qua- ternary ammonium salt had a strong bactericidal effect on Streptococcus mutans （P〈0.01）. Conclusion The nano-silica particle grafted with quaternary ammonium salt has a strong antibacterial property and could be used to improve dental composite resin antibacterial property.

关 键 词：复合树脂 抗菌性 无机填料 季铵盐 

分 类 号：R783.1[医药卫生—口腔医学]