AKAP-4、NY-ESO-1在肺癌中的表达及意义  

Expression and clinical significance of AKAP-4 and NY-ESO-1 antigens in lung cancer

作　　者：韩秀晶[1] 林云恩[2] 王建龙[3] 刘桂红[2] 向波[1] 廖伟娇[1] 

机构地区：[1]广州医学院第一附属医院检验科,广州市510120 [2]广州医学院第一附属医院病理科,广州市510120 [3]广州医学院检验系本科生,广州市510120

出　　处：《实用医学杂志》2012年第18期3004-3006,共3页The Journal of Practical Medicine

基　　金：广州医学院第一附属医院(编号:y200910gyfy);广州医学院(编号:2010A08)

摘　　要：目的:探索AKAP-4、NY-ESO-1在原发性肺癌组织中的表达及意义。方法:应用间接酶免疫组化技术检测AKAP-4、NY-ESO-1在72例肺癌组织中的表达情况,并分析其与肺癌分型和淋巴结转移的关系。结果:AKAP-4、NY-ESO-1阳性表达率分别为63.9%、11.1%;2种抗原在肺腺癌和肺鳞癌中的表达差异无显著性(P>0.05);2种抗原与淋巴结转移无相关性。结论:AKAP-4、NY-ESO-1在部分肺癌中表达,与肺癌分型及转移不相关。Objective To explore the expression and significance of AKAP-4 and NY-ESO-1 in primary lung carcinoma. Methods Indirect enzyme immunohistochemical methods were performed on the paraffinembedded tissues from 72 patients with primary lung cancer. Then the correlations between the antigens and primary lung carcinomas histological types, lymph nodes metastasis were analyzed. Results The positive expression rates of AKAP-4, NY-ESO-1 were 63.9 % （46/72）, 11.1% （8/72）, respectively. The expressions of AKAP-4 and NY-ESO-1 between lung adenocarcinoma and squamous cell lung carcinoma were not different significantly （P 〉 0.05）. 2 antigens were not associated with lymph nodes metastasis. Conclusion NY-ESO-1 and AKAP-4 antigens express in part of lung cancer, and are not associated with lung cancer sub-type and lymph nodes metastasis.

关 键 词：肺肿瘤 AKAP-4 NY-ESO-1 免疫组化 

分 类 号：R734.2[医药卫生—肿瘤]