胶质瘤相关癌基因1在乳腺癌亚型中的表达及意义  

Expressions of Gli1 in molecular subtypes of breast cancer and its significance

作　　者：刘夕水[1] 曾朋[2] 李曦洲[1] 隋金珂[1] 吴燕梅[1] 杜磊[1] 施俊义[1] 

机构地区：[1]第二军医大学附属长海医院甲状腺乳腺外科,上海200433 [2]武警江西总队医院普外科,330030

出　　处：《临床肿瘤学杂志》2012年第9期805-808,共4页Chinese Clinical Oncology

摘　　要：目的研究胶质瘤相关癌基因1(Gli1)的表达与乳腺癌各分子亚型的关系及意义。方法免疫组化法检测乳腺癌组织中Gli1表达,并探讨其与雌激素受体(ER)、孕激素受体(PR)、人表皮生长因子受体-2(HER-2)、Ki-67表达的关系,根据4种因子的表达情况进行分组并分析Gli1在Ki-67相关各分子亚型中的表达情况。结果 Gli1表达在ER阳性和阴性、Ki-67高表达和低表达及TNM不同分期之间差异均有统计学意义(P<0.05)。Luminal A型、Luminal B型、HER-2过表达型、Basal-like型中Gli1阳性率分别为51.35%、81.25%、88.24%和96.15%,Luminal A型的阳性率最低,且以低表达为主,与其他亚型比较差异均有统计学意义(P<0.05)。结论 Gli1在Luminal A型乳腺癌中以低表达为主,可以作为接受单纯内分泌治疗的判断依据之一。Gli1高表达主要在Luminal B型、HER-2过表达型及Basal-like型乳腺癌中,并可能成为Basal-like型乳腺癌潜在的治疗靶点。Objective To investigate the expressions of glioma-associated oncogene 1 （ Glil ） in molecular subtypes of breast cancer and the relevant significance. Methods The expression of Glil was measured in breast cancer tissues by immunohistochemis- try. The relationship between Glil and the expressions of estrogen receptor （ER）, progesterone receptor （PR）, human epidermal growth factor receptor-2 （HER-2） and Ki-67 was analyzed. Furthermore, the differences of Glil expression among different Ki-67 re- lated molecular subtypes were discussed. Results We found statistically significant differences in the distribution of the Glil expres- sion between different levels of ER, Ki-67 and TNM stage （P 〈0. 05）. The Gill-positive rates of luminal A subtype, luminal B sub- type, HER-2 enriched subtype and basal-like subtype were 51.35% , 81.25% , 88.24% and 96. 15% , respectively. Compared with other subtypes, the positive rate of Glil expression in luminal A subtype was lowest and the expression of Glil was mainly low-level with significant difference （P 〈 O. 05）. Conclusion The Glil in luminal A type was mainly low-expressed, and it may be used as a diagnostic evidence for single endocrine therapy. High expression of Glil mainly existed in luminal B subtype, HER-2 enriched subtype and basal-like subtype, which was a possible potential therapeutic target for basal-like subtype.

关 键 词：乳腺癌 分子分型 胶质瘤相关癌基因1 KI-67 

分 类 号：R737.9[医药卫生—肿瘤]