低钾性周期性瘫痪52例临床分析  

Clinical Analysis of 52Patients with Hypokalemic Periodic Paralysis

作　　者：谢荣堂[1] 赵玉芳[1] 

机构地区：[1]解放军264医院神经内科,太原030001

出　　处：《解放军医药杂志》2012年第9期18-20,共3页Medical & Pharmaceutical Journal of Chinese People’s Liberation Army

摘　　要：目的探讨低钾性周期性瘫痪的临床特征。方法回顾性分析2008年10月—2010年10月我院收治的52例低钾性周期性瘫痪的临床资料。结果 52例低钾性周期性瘫痪中原发性低钾性周期性瘫痪37例,继发性低钾性周期性瘫痪15例,继发于甲状腺功能亢进症12例、远端肾小管性酸中毒2例、原发性醛固酮增多症1例。主要临床表现为对称性肢体瘫痪,近端重于远端,从下肢发展到上肢。血清钾均降低,肌酸磷酸激酶(CK)增高12例。出现典型低钾性心电图改变30例。口服及静脉补钾为主要治疗措施。转归:痊愈51例,出现室颤死亡1例。结论低钾性周期性瘫痪病因复杂多样,认识原发性及继发性低钾性周期性瘫痪的临床特征,对诊断、治疗意义重大。Objective To explore the clinical characteristics of hypokalemic periodic paralysis （HOPP）. Methods Clinical data of 52 patients with HOPP during October 2008 and October 2010 in our hospital were retrospectively analyzed. Results Among 52 patients with HOPP, there were 37 patients with primary hypokalemic periodic paralysis and 15 patients with secondary HOPP including 12 patients with hyperthyroidism, 2 patients with distal renal tubular acidosis and 1 patient with primary aldosteronism. The main clinical features of HOPP were the symmetrical limbs paralysis ; proximalend was severer than that of distal end and lower limbs was earlier than that of upper limbs. All patients＇ serum potassium level decreased, 12 patients＇ creatine kinase （CK） increased. 30 patients＇ typical hypokalemic ECG changed. Oral and intravenous supplementation of potassium was the main treatment. Outcome： 51 patients were cured and 1 case died of ventricular fibrillation. Conclusion The causes of HOPP are complex and diverse, and it is very important to learn the clinical characteristics of primary and secondary periodic paralysis for diagnosis and treatment of HOPP.

关 键 词：低钾性周期性麻痹 低钾血症 甲状腺功能亢进症 

分 类 号：R746.3[医药卫生—神经病学与精神病学]