主成分和二肽分析抗癌晶体蛋白氨基酸组成特征  

The characteristics of anmino acid composition for parasporal crystal proteins with cancer cell-killing activities

作　　者：洪雪梅[1] 林毅[2] 

机构地区：[1]华侨大学信息学院,厦门361021 [2]华侨大学化工学院生物工程与技术系,厦门361021

出　　处：《生物信息学》2012年第3期174-176,共3页Chinese Journal of Bioinformatics

基　　金：教育部科学技术研究重点项目(211205);福建省高等学校新世纪优秀人才支持计划;福建省自然科学基金(2011J01221)

摘　　要：主成分分析结果表明,抗癌晶体蛋白的氨基酸组成满足公式:0.340C+0.358D+0.518E+0.109G+0.478H+0.525L+0.148N+0.565R+0.520W+0.123Y<0.260A+0.408F+0.033I+0.142K+0.246M+0.435P+0.515Q+0.571S+0.444T+0.110U–0.7。二肽组成分析结果表明,抗癌晶体蛋白中S*型二肽含量最高,A*、M*、P*及Q*型二肽次之,其含量也很高。研究结果初步揭示了抗癌晶体蛋白的氨基酸组成特征,为进一步深入研究其构效关系奠定了基础。The characteristics of anmino acid composition for parasporal crystal proteins with cancer cell - killing ac- tivities were presented. Principle Component Analysis showed that ifO. 340C ＋ 0. 358D ＋ 0.518E ＋0. 109G ＋ 0.478H ＋ 0.525L ＋ 0.148N ＋ 0.565R ＋ 0.520W ＋ 0.123Y 〈 0.260A ＋ 0.408F ＋ 0.0331 ＋ 0.142K ＋ 0.246M ＋ 0.435P ＋ 0.515Q ＋ 0.571S ＋ 0.444T ＋ 0. ll0U - 0.7, a parasporal crystal protein had anti- cancer activities. Dipeptide composition analysis showed that S ＊ dipeptide was the most abundant for a parasporal crystal protein had anticancer activities, and the dipeptide A＊ , M ＊ , P＊ and Q ＊ were also abundant.

关 键 词：抗癌晶体蛋白 氨基酸组成 主成分分析 二肽组成 构效关系 

分 类 号：Q71[生物学—分子生物学]