抑郁症患者血清CRP、CER、Hcy和Anti-CCP抗体的浓度变化  

Changes of Serum CRP,CER,Hcy and Anti-CCP Concentrations in Patients with Depression

作　　者：唐亚梅[1] 周利君[1] 刘勇[2] 秦立新[1] 

机构地区：[1]中南大学湘雅二医院检验科,湖南长沙410011 [2]中南大学湘雅二医院精神卫生研究所

出　　处：《实用预防医学》2012年第9期1399-1401,共3页Practical Preventive Medicine

摘　　要：目的探讨抑郁症患者血清C-反应蛋白(C-reactive protein,CRP)、铜蓝蛋白(copper-protein,CER)、同型半胱氨酸(Homocysteinc,Hcy)及抗环瓜氨酸肽抗体(anti-CCP)与抑郁症的关系。方法收集本院确诊的抑郁症患者55例,健康体检者30例,采用速率散射比浊法测血清CRP和CER,酶法测血清Hcy,酶联免疫吸附法测血清anti-CCP抗体,比较抑郁患者和正常对照人群的组间差异。结果与对照组比较,抑郁患者血清CRP水平无显著性变化(P>0.05),CER水平显著降低(P<0.05),Hcy和Anti-CCP水平均显著升高(P<0.05)。结论抑郁患者存在免疫炎症和自身免疫反应,CER、Hcy和anti-CCP均可能参与了抑郁症的病理进程。Objective To investigate the correlations of the levels of serum C- reactive protein （CRP）, ceruloplasmin （CER）, homocysteine （Hcy） and anti - cyclic citmllinated peptide antibody （anti - CCP） with depression. Methods Serum was collected from 55 patients with depression （depression group） and 30 health adults （control group）. The levels of serum CRP and CER were determined by rate nephelometry. Serum anti - CCP concentration was measured by enzymatic - linked immu- nosorbent assay （ELISA） and serum Hey was detected by enzyme method. The differences of serum CRP, CER, Hcy and anti - CI2P levels were compared between the depression group and the control group. Results Compared with the control group, the serum CRP level of the depression group was not statistically different（ P 〉 0.05 ）, while the serum CER concentration was significantly decreased （P〈0.05）and serum Hcy and anti- CCP were markedly increased（P〈0.05）. Conclusions Immu- nological inflammation and autoimmune reaction do exist in depression patients. CER, Hey and anti - CCP may all participate in the pathological process of depression.

关 键 词：抑郁症 C-反应蛋白 铜蓝蛋白 同型半胱氨酸 抗环瓜氨酸肽抗体 

分 类 号：R749.4[医药卫生—神经病学与精神病学]