小牛血去蛋白提取物在Epi-lasik治疗近视中的应用  

Clinical investigation of protein-free calf blood extract for epipolis laser in situ keratomileusis on myopia

作　　者：李盈龙[1,2] 彭小宁[1,2] 方向东[1,2] 吴帅辉[1,2] 

机构地区：[1]中国安徽省合肥市第一人民医院眼科 [2]安徽医科大学第三附属医院眼科,230061

出　　处：《国际眼科杂志》2012年第10期1876-1879,共4页International Eye Science

摘　　要：目的:探讨小牛血去蛋白提取物在Epi-lasik术中应用的安全性和临床疗效。方法:观察在本院行Epi-lasik手术的患者112眼,所有病例随机分为A,B两组:A组(小牛血去蛋白提取物组)58眼,B组(重组人表皮生长因子衍生物组)54眼,两组分别在Epi-lasik术后,立即用小牛血去蛋白提取物和重组人表皮生长因子衍生物眼药水,并观察患者术后刺激症状、术后角膜上皮瓣生长情况、术后视力及达到术前最佳矫正视力的时间、haze等情况,随访6～12mo。结果:A组的角膜上皮瓣生长情况要好于B组,两组间的差异有统计学意义(P<0.05)。术后1mo检查,A组有45眼(77.6%)达到术前最佳矫正视力,B组有32眼(59.3%),两组差异有统计学意义(P<0.05)。在达到术前最佳矫正视力的时间上,A组的大部分患者在术后1wk以内达到,而B组的患者多在术后2wk以后达到,两组差异有统计学意义(P<0.05)。两组在对术后haze的影响方面没有显著性差异(P>0.05)。结论:在Epi-lasik手术中应用小牛血去蛋白提取物,可以减轻角膜上皮瓣的水肿,缩短术后视力恢复的时间,改善干眼症状,安全有效,具有良好的应用前景。AIM： To evaluate the safety and clinical effect of protein- free calf blood extract after epipolis laser in situ keratomileusis（Epi-LASIK）surgery. METHODS： Totally 112 eyes with Epi-LASIK were randomly divided into Group A（protein-free calf blood extract eye gels）and Group B（recombinant human epidermal growth factor, rhEGF）： Group A with 29 patients 58 eyes were treated by protein-free calf blood extract eye gels and Group B with 27 patients 54 eyes were treated by rhEGF eye drops. In each group after Epi-LASIK, the drug was used immediately. Postoperative irritation, growth of epithelial flap, postoperative visual acuity, time to achieve the preoperative best-corrected visual acuity, haze development etc were observed for 6-12 months. RESULTS： The growth of epithelial flap in the Group A was better than the Group B and there was statistically significant difference（P〈0.05）. One month after surgery, 45 eyes（77.6%）in the Group A and 32 eyes（59.3%）in the Group B achieved the preoperative best-corrected visual acuity which was statistically significant（P〈0.05）. The time to achieve the preoperative best-corrected visual acuity in most Group A patients was shorter than 1 week while in the Group B it was longer than 2 weeks, which was statistically significant（P〈0.05）. There was no significant difference in haze development between 2 groups（P〉0.05）. CONCLUSION： Application of protein-free calf blood extract after Epi-LASIK can relieve epithelial flap edema, shorten time of visual acuity rehabilitation and alleviate the sensation of dry eye. It is a safe, effective method and presents a captivating prospect.

关 键 词：小牛血去蛋白提取物 重组人表皮生长因子衍生物 机械法准分子激光角膜上皮瓣下磨镶术 

分 类 号：R779.63[医药卫生—眼科]