外周血白细胞端粒长度与脑梗死的相关性研究  

Association of Telomere Length with Cerebral Infarction

作　　者：姜昕[1] 黄四春[2] 郭毅[2] 

机构地区：[1]暨南大学第二临床医学院心内科,广东深圳518020 [2]暨南大学第二临床医学院神经内科,广东深圳518020

出　　处：《神经损伤与功能重建》2012年第5期324-326,386,共4页Neural Injury and Functional Reconstruction

基　　金：广东省医学科研基金(No.A2009589)

摘　　要：目的:探讨脑梗死患者外周血白细胞端粒长度的变化及二者之间的关系。方法:应用实时荧光定量PCR方法检测70例脑梗死患者(病例组)和70例健康对照者(对照组)外周血白细胞相对端粒长度的变化,同时检测2组血脂、血糖、超敏C反应蛋白、血压等指标。结果:相对端粒长度病例组和对照组分别为(0.98±0.84)、(2.05±0.98),前者显著缩短(P<0.001)。结论:端粒长度的缩短与脑梗死发生具有相关性。Objective：To investigate association of telomere length and cerebral infarction.Methods： Seventy patients with ischemic strokes were recruited for the study and 70 healthy ones were treated as the controls.Leukocyte telomere length was measured with real-time Polymerase Chain Reactions in all subjects.Blood Lipids,blood glucose,high-sensitivity C-reactive protein,blood pressure were measured.Results： The mean leukocyte telomere length of the patients was significantly shorter than that in the controls [（0.98±0.84）＆（2.05±0.98）,P〈0.001].Conclusion： The shorten telomere length is related to cerebral infarction.

关 键 词：端粒长度 脑梗死 动脉粥样硬化 

分 类 号：R741[医药卫生—神经病学与精神病学] R741.02[医药卫生—临床医学]