血管性认知功能障碍相关危险因素的临床研究  

Risk Factors in Patients with Vascular Cognitive Impairment

作　　者：郭建敏[1] 谭倩[1] 李倩[2] 彭海[2] 

机构地区：[1]湖北省新华医院神经内科,武汉430071 [2]华中科技大学同济医学院附属协和医院神经内科,武汉430022

出　　处：《神经损伤与功能重建》2012年第5期348-350,389,共4页Neural Injury and Functional Reconstruction

摘　　要：目的:探讨血管性认知功能障碍(VCI)相关危险因素及同型半胱氨酸(Hcy)与认知功能的相关性。方法:选取63例有脑血管病危险因素的受试者,用MMSE、MoCA量表进行认知功能评估,发现VCI 32例(VCI组),认知功能正常31例(对照组)。采用化学免疫发光法测定受试对象血浆中Hcy浓度,酶学方法测定血糖、血脂浓度。结果:VCI组血浆Hcy水平明显高于对照组,差异有统计学意义(t=4.386,P<0.001)。VCI组Hcy水平与MoCA评分有相关性(R=0.754,P=0.012)。结论:血糖、血脂及Hcy水平与VCI相关。Objective：To explore the risk factors in patients with vascular cognitive impairment（VCI） and to investigate the relationship between VCI and plasma homocysteine（Hcy）.Methods：Sixty three cases with vascular risk factors were included in our study.Thirty-two of them in the VCI group and 31 in the normal cognition group according to MMSE and MoCA tests.Blood sugar and blood lipoids levels were examined by enzymology.The plasma Hcy concentration was detected by chemoimmunology.Results：The mean plasma level Hcy was significantly higher in the VCI group than that in the normal cognition group（P〈0.001）.Plasma level of Hcy was negatively associated with rate of MoCA（P=0.012）.Conclusion：Blood sugar,blood lipoids levels and Hcy levels are related to VCI.

关 键 词：血管性认知功能障碍 同型半胱氨酸 危险因素 

分 类 号：R741[医药卫生—神经病学与精神病学] R741.02[医药卫生—临床医学]