妊娠中期血清标记物检测在唐氏综合征产前筛查中的意义  

Effectiveness of second trimester serum marker screening for Down's syndrome

作　　者：柳芳[1] 梁红艳[1] 李艳丽[1] 姜晓峰[1] 

机构地区：[1]哈尔滨医科大学附属第四医院检验科,黑龙江哈尔滨150001

出　　处：《哈尔滨医科大学学报》2012年第4期367-369,共3页Journal of Harbin Medical University

基　　金：哈尔滨市科技创新人才专项资金项目(RC2007XK00-4033)

摘　　要：目的探讨妊娠中期血清标记物在唐氏综合征(DS)产前筛查中的意义。方法分别用血清二联筛查与三联筛查方法进行孕中期胎儿唐氏综合征产前筛查试验,孕妇胎龄为15～21周,对两种筛查方法的检出率及假阳性率进行分析,同时结合ROC曲线分析两种血清筛查方法的敏感性并相互比较。结果在5 063例孕妇中6例为DS胎儿,二联和三联筛查的DS检出率分别是50%和83.3%,假阳性率分别为2.2%和2.1%,ROC分析得到的曲线下面积(AUC)分别为0.62(95%CI:0.583～0.707)和0.85(95%CI:0.795～0.880)。结论孕中期血清筛查胎儿DS试验具有很好的参考价值,而血清三联筛查方法明显优于血清二联筛查。To investigate the effectiveness of serum markers analysis for Down＇ s syndrome （DS） during the second trimester prenatal screening. Methods Second trimester screening for DS were examined in pregnant women with a singleton pregnancy of 15 -21 weeks of gestation by double serum marker screening and triple screening methods. Results With double marker and triple marker analysis, the detection rate of DS were 50% and 83.3%, false positive rate were 2.2% and 2.1% respectively. With receiver operating characteristic curve （ROE） analysis, area under the curve （AUC） were 0.62 （95% CI： 0.583-0.707） and 0.85 （95 % CI ： 0. 795 - 0. 880 ） respectively. Conclusion screening using serum is more effective than marker analysis has a rattling reference value, double marker analysis for detection of DS. Second trimester prenatal and triple marker analysis

关 键 词：唐氏综合征 产前筛查 妊娠中期 

分 类 号：R714.55[医药卫生—妇产科学]