人脑胶质瘤中神经生长因子表达与组织病理分级及预后的关系  

Expression of nerve growth factor in glioma and the relationship with the pathological grade and prognosis

作　　者：陆新宇[1] 陆培松[1] 李巧玉[1] 杨勇[1] 

机构地区：[1]江苏大学附属人民医院神经外科,江苏省镇江市212001

出　　处：《中华实用诊断与治疗杂志》2012年第10期958-960,共3页Journal of Chinese Practical Diagnosis and Therapy

基　　金：江苏省自然科学基金项目(BK2008235)

摘　　要：目的探讨人脑胶质瘤中神经生长因子(nerve growth factor,NGF)的表达特点,了解其与肿瘤组织病理分级及预后间的相关性。方法观察86例脑胶质瘤患者脑胶质瘤组织及10例脑外伤行内减压术患者正常脑组织中NGF表达情况,并分析NGF核阳性率与脑胶质瘤病理分级及预后的关系。结果 NGF在正常脑组织中主要分布于细胞质,而在胶质瘤组织中分布于细胞质及细胞核中;高级别胶质瘤组NGF核阳性率(69.0%)高于低级别组(32.2%)(P<0.05);胶质瘤中NGF表达阳性者中位生存时间低于阴性者(P<0.05)。结论 NGF在脑胶质瘤中水平变化与胶质瘤组织病理分级、预后密切相关。Objective To study the expression of nerve growth factor （NGF） in glioma and the relationship with the pathological grade and prognosis. Methods The expression of NGF was detected with immuno-histochemical method in 86 patients with glioma and 10 brain trauma patients receiving decompression surgery. The relationship of NGF nuclear positive rate with pathological grade and prognosis was analyzed. Results NGF-positive immunoreactive products were distributed in both cytoplasm and nucleus of glioma, but were only located in cytoplasm of traumatic brain injury tissue. NGF nuclear-positive rate （NPR） of grades III to IV gliomas （69.0%） was higher than that of grades I to U gliomas （32.2%） （P〈0.05）. The median survival time was longer in positive NGF glioma patients than that in negative NGF glioma patients （P〈0.05）. Conclusion The expression of NGF is closely correlated with the pathological grade and prognosis, and may participate in the tumorigenesis of glioma.

关 键 词：胶质瘤 神经生长因子 病理分级 预后 

分 类 号：R739.4[医药卫生—肿瘤]