垂盆草片的成型工艺研究  

Study of Forming Progress of Sedum Sarmentosum Bunge Tablet

作　　者：冷静[1] 沈浩 邹亮[3] 王兵[1] 刘道刚[1] 黄坤[1] 

机构地区：[1]重庆市中医院,重庆400021 [2]重庆华森制药有限公司,重庆401147 [3]成都大学生物产业学院,四川成都610106

出　　处：《成都大学学报（自然科学版）》2012年第3期218-220,227,共4页Journal of Chengdu University（Natural Science Edition）

基　　金：重庆市卫生局中医药科研项目--基于中药固体制剂吸湿特性的配方辅料筛选数学模型研究(2010-2-150)资助项目

摘　　要：为优选垂盆草片的成型工艺,改善其吸湿性,考察了不同辅料对垂盆草片成型性、吸湿性和临界相对湿度的影响,筛选出垂盆草片的最优辅料及处方组成,并测定颗粒的临界相对湿度.实验结果表明,垂盆草片最佳成型工艺为:浸膏粉与淀粉、糊精和微粉硅胶按55.6∶80∶15∶5的比例混匀,以95%乙醇为润湿剂,1%的硬脂酸镁作为润滑剂,湿法制粒压片,所制颗粒临界相对湿度为66%.采用该法所制片剂成型性、崩解性好,硬度适宜,且不易吸湿.To optimize the formulation procedure of sedum sarmentosum bunge tablet and improve its mois- ture absorption, the impacts of different exeipients on the formability, hygroseopieity and critical relativehumidity of sedum sarmentosum bunge tablet were investigated. The best excipients and composition of pre- scription for sedum sarmentosum bunge tablet were filtered and the critical relative humidity of the tablets were measured. The results show that the optimized formulation procedure is that the mixture is composed of extract powder, starch, dextrin and silicon dioxide by a ratio of 55.6： 80：15：5,95 % ethanol as the wetting agent, 1% magnesium steamte as lubricant. The critical relative humidity of the tablet made by wet granule compression technique was 66%. It is eoncluded that the tablet has ideal formability, disintegration, moder- ate rigidity and be resistant to moisture.

关 键 词：垂盆草片 成型工艺 吸湿性 

分 类 号：R044.4[医药卫生]