急性闭角型青光眼房角开放度与生物测量相关性  

Correlations between opening degree and biometric characteristics of anterior chamber angle in primary acute angle closure glaucoma

作　　者：边俊杰[1] 戴惟葭[1] 刘大川[1] 

机构地区：[1]首都医科大学宣武医院眼科,北京100053

出　　处：《临床眼科杂志》2012年第5期385-388,共4页Journal of Clinical Ophthalmology

摘　　要：目的探讨急性闭角型青光眼(AACG)房角关闭的危险因素。方法选择首次单眼发作的AACG患者40例(40只眼),浅前房患者50例(50只眼),正常人群50例(50只眼)。按照年龄进行分组,采集相干光断层扫描(OCT)前房角图像并量化房角开放度(OA)。应用接触式A超收集上述临床资料的中央前房深度(ACD)、晶状体厚度(LT)等生物测量数据,并同时引入晶状体位置(LP)、前房拥挤比(CCR)等观察指标,应用多元线性回归分析不同年龄段ACD、LT、LP、CCR与OA的相关性。结果 50～59岁年龄段OA与ACD(t=3.697,P=0.002)、CCR(t=-4.466,P=0.001)和LP(t=1.888,P=0.031)呈线性回归关系。60～69岁年龄段OA与ACD(t=2.237,P=0.034)、CCR(t=-6.772,P=0.001)和LP(t=2.746,P=0.012)呈线性回归关系。70岁以上年龄段OA与ACD(t=15.698,P<0.001)呈线性回归关系。结论晶状体因素(晶状体厚度、晶状体位置、前房拥挤比)是房角变窄以致发生急性关闭的危险因素,其中前房拥挤比可以科学、准确的评价前房拥挤状态,是评估房角关闭的敏感指标之一。Objective To explore the risk factors leading to acute angle closure glaucoma. Methods 40 eyes of 40 cases with unilateral AACG in first attack were chosen into the study. 50 eyes of 50 cases of shallow anterior chamber and 50 eyes of 50 cases of normal individuals were also enrolled. OCT images of anterior chamber angle in each group were collected and the opening angle （OA） of anterior chamber was quantified. The biometric characteristics data including anterior chamber depth （ ACD）, lens thickness （ LT） were measured by A-ultrasound and the other factors were introduced in this study as well： lens position （LP）, chamber crowding rate {CCR）. The correlations between OA and ACD, LT, LP and CCR were analyzed using multiple linear regression in different groups divided by different age. Results In group aged 50 -59, there was linear regression relationship between OA and ACD （ t = 3. 697, P = 0.002 ）, CCR （ t = - 4. 466, P =0.001 ） and LP （ t = 1. 888, P = 0. 031 ）. In group aged 60-69, there were linear regression relationship be- tween OA ana ACD （t = ：2.237, P = 0.034）, CCh （t = -6.772, P =0.001） as well asLP （t =2.746, P = 0. 012 ）. Iv. gloup aged above 70, linear regression relationship between OA and ACD （ t = 15. 698, P 〈 0.001 ） was appeared in this result. Conclusion Lens-related factors including LT, LP and CCR are the most likely risk factors accounting for acute angle closure. CCR is considered in this study to be more scientific, more accurate to evaluate anterior chamber crowd that might be one of the most sensitive indicator to assess the risk of angle-closure.

关 键 词：青光眼 闭角型 房角 晶状体 生物测量 

分 类 号：R775.2[医药卫生—眼科]