血栓心脉宁片对急性血瘀大鼠血浆NO/ET-1的影响  

Study of Xueshuan Xinmaining Tablets′s effects on expression of NO /ET-1 on Acute Blood-Stasis Model Rats

作　　者：张晓天[1] 王凯[2] 周晓辉[3] 彭蕊[1] 王鑫磊[1] 呼洁[1] 赛景影[1] 王放[1] 孟祥辉[1] 

机构地区：[1]吉林大学白求恩医学院,吉林长春130021 [2]吉林大学第一医院 [3]长春医学高等专科学校

出　　处：《中国实验诊断学》2012年第9期1575-1577,共3页Chinese Journal of Laboratory Diagnosis

基　　金：吉林省科技厅资助项目(201205014)

摘　　要：目的观察血栓心脉宁片对急性血瘀大鼠血浆一氧化氮/内皮素-1(NO/ET-1)的影响。方法采用两次注射肾上腺素、冰水浴的方法建立急性血瘀大鼠模型,观察血栓心脉宁片对大鼠血浆NO及ET-1的影响。结果急性血瘀模型大鼠血浆NO含量明显降低(P<0.01),血浆ET-1含量明显升高(P<0.01);血栓心脉宁片高、中、低剂量组作用后均可显著升高急性血瘀大鼠血浆NO含量(P<0.05、P<0.01),降低血浆ET-1含量(P<0.01),以中剂量组效果最为明显,与步长脑心通颗粒具有相似的作用。结论血栓心脉宁片可促进NO合成和分泌,抑制ET-1表达,有利于恢复NO/ET-1平衡,对急性血瘀的改善具有积极作用。。Objective To observe the effects of Xueshuan Xinmaining tablets on expression of NO / ET-1 on acute blood stasis rats.Methods The acute blood-stasis model rats were made by being soaked in ice water after being injected adrenaline hydrochloride.The influence of Xueshuan Xinmaining tablets on expression of NO and ET-1 in the model rats were observed.Results Plasma NO content decreased and ET-1 level increased significantly in the rat of acute blood-stasis（P〈0.01）.Three groups of the Xueshuan Xinmaining tablets could markedly increase the NO（P〈0.05、P〈0.01） and reduce the ET-1（P〈0.01） of acute blood-stasis rats.Among of three groups,the medium group＇s effect is the best,and it is similar to Buchang Naoxintong group.Conclusion Xueshuan Xinmaining tablets could increase the NO level and decrease ET-1 level of acute blood-stasis rats,benifiting for keeping balance of NO/ ET-1 and has positive effects on prevention and cure acute blood stasis.

关 键 词：血栓心脉宁片 急性血瘀大鼠 NO ET-1 

分 类 号：R285.5[医药卫生—中药学]