还原型谷胱苷肽对阿尔茨海默病患者血清HS-CRP、IL-6及MDA的影响  

To investigate of the effect of the reduced glutathione on the cognitive unction,the serum hypersensitive C-reactive protein,Interleukin-6 and Malondialdehyde of Alzheimer's disease

作　　者：郭宏伟 李伟华 张春霞 吴定国 

机构地区：[1]武汉市武昌医院神经内科,湖北武汉430063

出　　处：《中国实验诊断学》2012年第9期1616-1618,共3页Chinese Journal of Laboratory Diagnosis

基　　金：武汉市卫生局临床医学科研项目(WX12D16)

摘　　要：目的观察还原型谷胱苷肽对阿尔茨海默病(AD)患者认知功能及血清超敏反应蛋白(HS-CRP)、白介素-6(IL-6)及丙二醛(SOD)的影响。方法将68例AD患者随机分为观察组36例,对照组32例。均予以常规指导,口服多奈哌齐片5mg,1/日治疗。观察组在此基础上加服还原型谷胱苷肽片,0.4g,3次/日,总疗程为12周。监测两组患者治疗前后MMSE评分、血清HS-CRP、IL-6、MDA的变化,并予以比较分析。结果①两组患者治疗后MMSE评分均较治疗前升高,差异经检验具有统计学意义(P<0.05)。观察组治疗后MMSE评分较对照组更高,但差异经检验不具统计学意义(P>0.05)。②治疗后、观察组血清HS-CRP、IL-6、MDA明显低于治疗前及对照组,差异经检验具有统计学意义(P<0.01或0.05)。对照组治疗前、后血清HS-CRP、IL6、MDA的差异,经检验则不具统计学意义(P>0.05)。结论还原型谷胱苷肽可用治于阿尔茨海默病,并可改善患者中枢神经系统的炎性反应和氧化应激状态。Objective To investigate of the effect of the reduced glutathione on the cognitive function,the serum hypersensitive C-reactive protein,Interleukin-6 and Malondialdehyde of Alzheimer＇s disease（AD）.Methods 68 AD patients were divided into observation group（n=36） and control group（n=32） randomly.Patients in control group only were treated with conventional therapy,oral donepezil tablets 5mg,qd.po.The Observation group were treated with conventional therapy and glutathione tablets,0.4,tid.po.the total course of 12 weeks.Changes in MMSE scores,serum HS-CRP,IL-6,MDA were observed in the two groups before and after treatment to compared the efficacy.Results ①The MMSE scores of all patients in two groups increased after treatment compared with before treatment,and the difference was significant（P〈0.05）,the observation group increased more obviously than the control group,but there was no significant difference of curative rate between the patients of two groups（P〈0.05）.②The serum hypersensitive C-reactive protein,Interleukin-4 and Malondialdehyde of the observation group was significantly lower than before treatment and control group（before and after treatment）,showed significant difference（P〈0.01 or 0.05）.The serum hypersensitive C-reactive protein,Interleukin-4 and Malondialdehyde of the control group before and after treatment had no difference（P〈0.05）.Conclusion The reduced glutathione can be used to treat Alzheimer disease,and improve the inflammatory response and oxidative stress state of patients central nervous system.

关 键 词：还原型谷胱苷肽 阿尔茨海默病 超敏反应蛋白 白介素-6 丙二醛 

分 类 号：R749.16[医药卫生—神经病学与精神病学]