1,2-肼二(二硫代甲酸甲酯)的合成及抑菌活性研究  

Study on Synthesis and Antifungal Activity of Dimethyl-1,2-Hydrazine Bis(Dithioformate)

作　　者：李振华[1] 尹文华 孙云明[1] 王艳丽[1] 丁彩真[1] 杨洪迪[1] 杨青[1] 董风英[1] 

机构地区：[1]青岛农业大学化学与药学院,山东青岛266109 [2]青岛市海泊河污水处理厂,山东青岛266021

出　　处：《山东农业科学》2012年第9期93-94,97,共3页Shandong Agricultural Sciences

基　　金：青岛农业大学高层次人才启动基金(630916)

摘　　要：以二硫化碳、水合肼、硫酸二甲酯等为原料,合成了1,2-肼二(二硫代甲酸甲酯)。其结构经熔点、红外光谱进行了确证。采用菌丝生长速率法研究了1,2-肼二(二硫代甲酸甲酯)的抑菌活性。结果表明:1,2-肼二(二硫代甲酸甲酯)对葡萄黑痘病菌、辣椒炭疽病菌、苹果腐烂病菌、棉花枯萎病菌和苹果轮纹病菌等5种供试病原菌都有很好的抑制作用,其EC50值均小于20 mg/L。其中对苹果腐烂病菌的抑制作用最强,其EC50值为2.2 mg/L。Dimethyl - 1,2 - hydrazine bis （dithioformate） was synthesized with carbon bisulfide, hydra- zinc hydrate, dimethyl sulfate and so on. Its structure was characterized by MP and IR and its antifungal activ- ities were studied by mycelia growth rate method. The results showed that it had good inhibition effects on Sphaceloma ampelinum, Colletotrichum capsici, Valsa mali, Fusarium oxysporum f. sp. vasinfectum and Physa- lospora piricola with the ECso values less than 20 mg/L. It had the strongest inhibiton effect on Valsa mali with ECs0 value as 2.2 mg/L.

关 键 词：1 2-肼二(二硫代甲酸甲酯) 合成 抑菌活性 

分 类 号：S482.22[农业科学—农药学]