酒精依赖患者立体定向伏隔核毁损术后1年健康状况及生存质量调查  

Life quality and health conditions one year after stereotactic ablation of nuclei accumbens in patients with alcohol dependence

作　　者：赵江涛[1] 常崇旺[1] 耿宁[1] 葛顺楠[1] 王学廉[1] 

机构地区：[1]第四军医大学唐都医院神经外科,西安710038

出　　处：《中国临床神经外科杂志》2012年第9期529-530,576,共3页Chinese Journal of Clinical Neurosurgery

摘　　要：目的探讨酒精依赖患者立体定向伏隔核毁损术后1年健康状况及生存质量变化。方法 2007年5月至2010年12月立体定向双侧伏隔核毁损术治疗酒精依赖患者33例。术后1年应用简明36项健康状况问卷(SF-36)和WHO生存质量测定量表简表(WHOQOL-BREF)评估患者健康状况及生存质量。结果术后1年患者戒断率为87.9%(29/33)、复饮率为12.1%(4/33);患者生存质量WHOQOL-BREF评分及健康状况SF-36评分较术前显著改善(P<0.05);术后患者主观感受的健康状况评分亦显著改善(P<0.05)。术后2例发生嗅觉障碍,均于6月内恢复;未发生明显的严重影响生活质量的并发症。结论立体定向伏隔核毁损术短期内对酒精依赖患者安全有效,可以作为严重酒精依赖患者在其他方法治疗均无效时的一种选择。Objective To explore the effect of stereotactic ablation of nuclei accumbens on the lite quality and health conditions in patients with alcohol dependence. Methods Thirty-three patients with alcohol dependence, who received 3 or above 3 times of systematical conservative treatment and relapsed into alcohol dependence in short term, were treated by the stereotactic ablation of the bilateral nuclei accumbens. The face-to-face survey in all the patient was carried out in outpatient service 1 year after the stereotactic surgery and the survey included the relapse, complications and answers to WHOQOL-BREF and SF-36 scales. Results The life quality and health situation were significantly improved 1 year after the stereotactic surgery compared to the preoperation in 29 （87.9%, 29/33） patients. Four patients （12.1%, 4/33） relapsed into alcohol dependence. Hyposmia occurred after the surgery in 2 patients （6.1%, 2/33） in whom the sense of smell returned to normal 4 and 6 months respectively after the surgery. Conclusion The stereotactic ablation of the bilateral nuclei accumbens is an effective and safe method to treat severe alcohol dependence.

关 键 词：酒精依赖 立体定向 伏隔核 毁损术 生存质量 健康状况 

分 类 号：R749.62[医药卫生—神经病学与精神病学]