替加氟对中晚期食管癌放疗增敏效果及副作用观察  

THE EFFECT OF TEGAFUR ON SENSITIZATION OF RADIOTHERAPY AND ITS INFLUENCE ON THE SIDE EFFECTS IN PATIENTS WITH MIDLATE STAGE ESOPHAGEAL CARCINOMA

作　　者：李增智[1] 李宁[1] 毛晓红[2] 杨杰[2] 宋丽阳[2] 张继国[3] 

机构地区：[1]沧州中西医结合医院放疗科,河北沧州061001 [2]青岛大学医学院药学系 [3]泰山医学院

出　　处：《齐鲁医学杂志》2012年第6期485-486,489,共3页Medical Journal of Qilu

摘　　要：目的观察口服抗代谢药替加氟在中晚期食管癌放疗中的增敏效果及对放疗副作用的影响。方法将128例初治中晚期食管癌病人随机分为2组,均采用直线加速器6MV-X线进行外照射放疗,靶区剂量为60～64Gy/(6～7)周。实验组自放疗当日口服替加氟,每次0.1～0.2g,每天3次,至放疗结束。对照组在放疗同时伍用顺铂20mg快速静滴,每周2次,按病人对药物的反应及耐受性给予4～6周的增敏。结果两组病人近期疗效差异无显著性,而骨髓抑制和胃肠道不良反应差异有统计学意义(χ2=10.25、3.75,P<0.05)。结论中晚期食管癌放疗并用替加氟增敏效果与顺铂相近,副作用轻微,病人耐受性较好。Objective To observe the effect of oral tegafur on sensitization of radiotherapy for midlate stage esophageal carcinoma （EC） and its influence on the side effects of radiation. Methods This study enrolled 128 initial treatment patients with midlate stage EC, and were randomized to two groups. They were treated with conventional fraetionated radiotherapy using linear accelerator 6 MV X ray with the target area dosage of 60-64 Gy/（6-7） weeks The patients in the experimental group were given tegafur, 0.1-0.2 g, three times a day, starting from the day of radiation and lasting until completion of radiotherapy; to those in the control group, rapid intravenous drip of cisplatin, 20 rag, twice a week, were given. All the patients received sensitiza tion of 4 6 weeks according to patients＇ response and tolerance to the drug. Results The difference between the two groups was not significant in terms of short term efficacy, but it was significant in terms of bone marrow depression and adverse reactions of gastrointestinal tract （x^2=10.25,3.75;P〈0.05）. Conclusion For patients undergoing radiotherapy for midlate stage EC, the outcome of using tegafur or cisplatin for sensitization is similar, but the side effects of the former is litter, and better tolerated.

关 键 词：食管肿瘤 替加氟 顺铂 辐射增敏药 放射疗法 

分 类 号：R735.105[医药卫生—肿瘤]