化学药物栓塞治疗后肝癌局部组织反应及碘元素含量分析  

The local tissue reactivity and distribution of iodine content after treatment by transcatheter arterial embolization

作　　者：谭云山[1] 纪元[1] 周燕南[1] 阿克苏 李晓萍 

机构地区：[1]上海医科大学中山医院病理科,上海200032

出　　处：《临床与实验病理学杂志》2000年第3期210-213,共4页Chinese Journal of Clinical and Experimental Pathology

基　　金：国家自然科学基金!资助项目 (No 391 60 0 34);江西省自然科学基金

摘　　要：目的 :探讨肝动脉栓塞化疗 (TAE)治疗肝癌后 ,其局部组织反应以及从形态学角度探讨碘化油滞留与肝癌组织坏死的关系。方法 :应用免疫组织化学、透射电镜观察其局部组织反应 ,用硫酸铈接触法及改良有关碘测定方法在HE大切片相应区分别取癌组织坏死区、残留癌组织区及癌周肝组织区测定碘元素含量。结果 :肉芽组织机化肿瘤坏死组织最后形成纤维包膜。纤维包膜内及残留癌组织内以T淋巴细胞浸润为主和巨噬细胞增生。电镜观察到癌细胞变性坏死以及癌细胞间淋巴细胞浸润。加碘化油TAE治疗肝癌组织坏死区碘元素含量最高 ,残留癌组织区其次 ,癌周肝组织最低。结论 :TAE治疗并不降低其局部抗肿瘤细胞免疫能力 ;带有化学抗癌药物的碘化油滞留栓塞肝癌微小血管可使肝癌组织坏死。Purpose To research the local tissue reactivity and effect of iodine with anti cancer drugs on the cancer tissue necrosis and the residual tumor tissues after treatment by transcatheter arterial embolization(TAE). Methods The pathologic changes were investigated immunohistochemically and ultrastructurally, and iodine contents in the necrotic tumor tissues and the residual tumor tissues and the liver tissues around tumor and were measured with a test of iodine content in tissues. Results A granulation tissue organized the necrotic tissues constructed the fibrocapsule of the tumor. Infiltrating cells in the capsule and the residual tumor tissues were mostly T lymphocytes and macrophages. T lymphocytes were seen between the degenerated carcinoma cells by electron microscope. The iodine TAE group had shown that there was the highest iodine content in the necrotic tissues and secondary in the residual tumor tissues and the lowest in the liver tissues around the tumor. Conclusion After treatment by TAE the local anti tumor immunity function is not lowered, and the highest iodine content in the necrotic tumor tissues has suggested that the necroses of tumor tissue are induced by iodine with anti cancer drugs.

关 键 词：肝肿瘤 碘含量 栓塞疗法 TAE 

分 类 号：R735.7[医药卫生—肿瘤]