度洛西汀和氯丙咪嗪治疗抑郁症并发糖尿病效果比较  

DULOXETINE VERSUS CLOMIPRAMINE IN THE TREATMENT OF DEPRESSION ASSOCIATED WITH DIABETES

作　　者：潘淑先[1] 王心蕊[1] 姜玉艳[1] 

机构地区：[1]青岛市精神卫生中心,山东青岛266034

出　　处：《青岛大学医学院学报》2012年第5期441-442,共2页Acta Academiae Medicinae Qingdao Universitatis

摘　　要：目的观察比较度洛西汀和氯丙咪嗪治疗抑郁症并发糖尿病的效果。方法将40例抑郁症并发糖尿病病人随机分为度洛西汀组、氯丙咪嗪组各20例。两组分别给予度洛西汀60mg/d、氯丙咪嗪25～300mg/d,治疗疗程8周。以汉密尔顿抑郁量表(HAMD)评定临床疗效,并检测空腹和餐后2h血糖。结果治疗后度洛西汀组抑郁症状的减轻与氯丙咪嗪组相当(P>0.05),空腹和餐后2h血糖较氯丙咪嗪组降低,但差异无显著性(P>0.05)。结论度洛西汀能有效减轻抑郁症并发糖尿病病人的抑郁症状,对血糖影响较小。Objective To compare the efficacy between duloxetine and clomipramine in the treatment of depression in patients with diabetes.Methods Forty patients with depression associated with diabetes were evenly randomized to Duloxetine-and Clomipramine-treatment group.The patients in Duloxetine-treatment group received Duloxetine 60 mg/d;and those in Clomipramine-treatment group were given Clomipramine 25-300 mg/d,the course was eight weeks for both groups.The clinical effect was evaluated by HAMD score,fasting blood glucose and 2-hour-after-meal blood glucose were detected.Results According to HAMD score,the relief of depressive symptoms of patients in Duloxetine group was similar to that in Clomipramine group（P〈0.05）.Fasting blood sugar and that two hours after meal was lower than that in Duloxetine group,but the difference was not significant（P〈0.05）.Conclusion Duloxetine can effectively relieve depression in patients with diabetes,but its influence on blood sugar is relatively low.

关 键 词：度洛西汀 氯丙咪嗪 抑郁症 糖尿病 治疗结果 

分 类 号：R749.42[医药卫生—神经病学与精神病学]