肥胖易感及肥胖抵抗动物模型的建立与评价  

Establishment of Obesity Prone and Obesity Resistant Rats Induced by High-fat Diet

作　　者：刘健敏[1] 郑龙[1] 张焕铃[1] 连伟光[1] 王俊霞[1] 徐增年[1] 刘树锋[1] 

机构地区：[1]河北医科大学实验动物学部,石家庄050017

出　　处：《科学技术与工程》2012年第28期7344-7346,共3页Science Technology and Engineering

基　　金：河北省高等学校科学技术研究指导项目(Z2011167);河北省科技计划项目(11277170);河北医科大学科研骨干人才培育计划项目(30900143)资助

摘　　要：建立肥胖易感(OP)和肥胖抵抗(OR)大鼠模型并进行评价。以高脂饲料喂饲雄性SD大鼠3周。根据体重筛选出OP和OR大鼠。继续喂饲高脂饲料10周,期间检测大鼠体重、体长,计算Lee’s指数、BMI指数。实验结束处死动物,测量体脂肪含量。OP组动物与对照组相比,体重、Lee’s指数、BMI指数、体脂含量等指标均具有显著性差异。OR组动物的各项指标与对照组动物相近,提示用高脂饮食诱导肥胖与肥胖抵抗的动物模型造模成功。To establish and evaluate the obesity prone and obesity resistant rat model, male sprague-dawley （SD） rats were divided into OR rats and OP rats after fed with high fat diet for3weeks. Measurements of body weight, body length, Lee＇s Index, body mass index （BMI） were performed. After the rats were sacrificed , body fat content was measured. There were significant differences between OP rats and control rats in body weight, Lee＇ s Index, body mass index （BMI） and ,body fat content. At the same time, there were no significant differences between OR rats and control rats. It is reliable and successful to establish the rats＇ model of obesity and obesity re sistance.

关 键 词：肥胖易感 肥胖抵抗 建立 评价 

分 类 号：R151.1[医药卫生—营养与食品卫生学]