先天性巨结肠的微环境病因学研究  

Progress on the etiology of mieroenvironment of Hirsehsprung＇ s disease

作　　者：许灵苍(综述)[1] 吕志葆(审校)[1] 

机构地区：[1]上海市儿童医院、上海交通大学附属儿童医院小儿外科,200040

出　　处：《国际儿科学杂志》2012年第5期488-490,共3页International Journal of Pediatrics

摘　　要：先天性巨结肠是一种复杂的先天性疾病，其特点是神经节细胞在肠管末端缺如，从而引起功能性肠梗阻。它是由基因和环境因素改变而引起的一种复杂疾病。近几十年，人们发现在早期胚胎阶段，肠壁微环境的改变能影响神经嵴母细胞的迁移和分化，是导致先天性巨结肠的重要病因之一。在早期胚胎阶段，肠壁微环境改变包括L1细胞黏附分子、神经生长因子、骨形态发生蛋白等。Hirschspmng＇s disease （HD） is a complex congenital disorder characterized by the absence of the intestinal ganglion cells in the distal intestine, causing functional colonic obstruction. It is a complex disease that results from alterations of the genetic factors and environment factors. In the last decades, people find that the alterations of intestinal microenvironment in primarily embryogenic period can affect migration,and differentiation of neural crest cells. So it is one of major causes for the appearance of HI）. Alterations of intestinal microenvironment in primarily embryogenic period include L1 cell adhesion molecules, nerve growth factor, bone morphogenetic proteins and so on.

关 键 词：先天性巨结肠 病因学 微环境 

分 类 号：R[医药卫生]