同步放化疗治疗晚期胰腺癌临床观察  

Clinical Observation of Concurrent Chemoradiotherapy for Advanced Pancreatic Cancer

作　　者：田素萍[1] 史曙霞[1] 杨保卫[1] 

机构地区：[1]济源市肿瘤医院放疗科,河南济源454650

出　　处：《肿瘤基础与临床》2012年第5期400-402,共3页journal of basic and clinical oncology

摘　　要：目的观察三维适形放疗(3-DCRT)联合吉西他滨同步化疗治疗晚期胰腺癌的疗效和毒副反应。方法 38例晚期胰腺癌患者采用3-DCRT,局部DT:50～56 Gy,20～25次;同时应用吉西他滨1 000mg.m-2,静脉滴注,d1,8,15,每28 d重复。结果 38例患者均可评价疗效,总有效率为76.32%,局部控制率为86.85%。6、12、24个月生存率分别为85.12%、65.21%和14.03%。毒副反应轻微,患者均能耐受。结论 3-DCRT联合吉西他滨同步化疗治疗晚期胰腺癌是安全、有效的。Objective To observe the effect and toxicities of three dimensional conformal radiation therapy （3- DCRT） plus concurrent gemcitabine chemotherapy for advanced pancreatic cancer. Methods Thirty-eight patients with advanced pancreatic cancer received 3-DCRT（50-56 Gy, 20-25 times） and gemcitabine （1 000 mg · m-2, d,.s.15, repeated every 28 days） at the same time. Results Of the 38 patients, the total effective rate was 76.32% , the local-regional control rate was 86.85%. The 6-, 12- and 24-month survival rates were 85.12%, 65.21% and 14.03%, respectively. The toxicities were mild. Conclusion 3-DCRT plus concurrent gemcitabine chemotherapy is safe and effective for advanced pancreatic cancer.

关 键 词：三维适形放疗 吉西他滨 胰腺癌 

分 类 号：R735.9[医药卫生—肿瘤] R730.58[医药卫生—临床医学]