胃肠道间质瘤28例临床病理分析  

A Clinicopathologic Study on 28 Cases of Gastrointestinal Stromal Tumors

作　　者：王星辉[1] 王雪飞 

机构地区：[1]寿光市人民医院病理科,山东寿光262700 [2]寿光市环保局,山东寿光262700

出　　处：《肿瘤基础与临床》2012年第5期426-428,共3页journal of basic and clinical oncology

摘　　要：目的探讨胃肠道间质瘤(GIST)的临床病理特点,分析其生物学行为与形态学的关系。方法回顾性总结分析28例GIST患者的临床病理资料,并复习相关文献。结果本组28例GIST患者中,发生在胃13例,小肠8例,结肠3例,食管2例,肠系膜1例,腹腔1例;高度恶性GIST 20例,低度恶性GIST 8例。镜下肿瘤组织由梭形细胞及上皮样细胞以不同比例混合而成。高度恶性GIST上皮样细胞比较增多。免疫组化标记显示CD117均为阳性。高度恶性组Ki-67阳性指数30%,低度恶性组Ki-67阳性指数3%。S-100及Actin仅2例灶状阳性,其余均阴性。结论上皮样细胞型GIST可能侵袭性更强,转移率更高;免疫组化标记Ki-67可能会成为评价其转移潜能的一个重要指标。Objective To study the clinicopathologic characteristics of gastrointestinal stromal tumors （GIST） , and to analyze the relationship between biological behavior and morphology. Methods The clinicopathologic data of 28 cases of GIST were studied and the related literatures were reviewed. Results Of all the 28 cases, 13 cases of the tumors were situated in stomach, 8 cases in small intestine, 3 eases in colon, 2 cases in esophagus, 1 case in mesentery and 1 case in peritoneal cavity; 20 cases of the highly malignant GIST, 8 cases of lowly malignant GIST. The tumor tissues had two kinds of cells ： spindle cells and epithelioid cells, they were different in proportion. The highly malignant GIST was mainly composed of epithelioid ceils. CD117 was positive of them all. The positive rate of Ki-67 was 30% in the highly malignant GIST, and was 3% in the lowly malignant GIST. S-100 and Actin were positive in the 2 cases, and were negative in the others. Conclusion Epithelioid GIST had higher invasion and metastasis, Ki-67 may be an important immunohistoehemical markers used to evaluated the tumor metastasis.

关 键 词：胃肠道间质瘤 上皮样 CD117 KI-67 转移 

分 类 号：R735[医药卫生—肿瘤]