去甲斑蝥素联合中药治疗老年晚期肝癌的疗效观察  

Efficacy Observation of Liver Cancer at the Later Stage for the Elderly Treated with Integration of Norcantharidin and Chinese Medicine

作　　者：初玉平[1] 沈琳 白羽[3] 

机构地区：[1]首都医科大学附属朝阳医院,北京100020 [2]北京大学肿瘤医院,北京100142 [3]北京大学第一医院,北京100034

出　　处：《世界中西医结合杂志》2012年第9期765-767,共3页World Journal of Integrated Traditional and Western Medicine

基　　金：民政部立项课题(民人教科字[2008]47-2-52)

摘　　要：目的观察去甲斑蝥素联合中药治疗老年晚期肝癌患者的临床疗效。方法将79例老年晚期肝癌患者随机分为治疗组(40例)和对照组(39例),治疗组采用中药汤剂加去甲斑蝥素治疗,对照组单纯接受化疗、介入或支持治疗。均以28 d为1个周期,至少治疗2个周期为合格病例。观察、比较两组患者中位生存期、肿瘤客观缓解率、生活质量卡氏评分。结果治疗组中位生存期为16个月,对照组11个月,两组比较,差异有统计学意义(P<0.01);两组肿瘤客观缓解率比较,差异有统计学意义(P<0.01);两组生活质量卡氏评分比较,差异有统计学意义(P<0.05);治疗组患者不良反应发生率明显少于对照组(P<0.05)。结论中西医结合治疗老年晚期肝癌可延长患者两年中位生存期,提高患者的生活质量。Objective To observe the clinical efficacy of the integration of norcantharidin and Chi- nese medicine in the treatment of liver cancer at the later stage for the elderly. Methods 79 cases of the elderly with liver cancer at the later stage were randomized into a treatment group （ 40 cases） and a control group （39 cases）. In the treatment group, the patients were treated with Chinese herbal decoction and norcan- tharidin, In the control group, the patients were simply treated with chemotherapy, intervention or support therapy. In both groups, the treatment of 28 days made 1 period. The cases were qualified in the research by receiving at least two - period treatment. The median survival time, tumor objective remission rate and the score of Kamofsky performance status （ KPS ） were observed and compared for the patients between two groups. Results The median survival time was 16 months in the treatment group and was 11 months in the control group, indicating the statistical significant difference in comparison（ P 〈 0.01 ）. The comparison of the tumor objective remission rate between two groups presented the statistical significant difference （P 〈 0.01 ）. The comparison of KPS score between two groups presented the statistical significant difference （ P 〈 0.05 ）. The incidence rate of adverse reaction for the patients in the treatment group was obviously lower than that in the control group （ P 〈 0.05 ）. Conclusion The integrated Chinese and western medicine prolongs the medi- an survival time and improves the quality of life for the elderly with liver cancer at the later stage.

关 键 词：老年晚期肝癌 中西医结合治疗 中位生存期 生活质量 

分 类 号：R735.7[医药卫生—肿瘤]