子宫内膜癌中血管生成拟态的临床意义  

Clinical significance of Vasculogenic mimicry in Endometrial carcinnoma

作　　者：廖丹[1,2] 禹正扬[1] 邓亚丽[2] 

机构地区：[1]南华大学附属第一医院肿瘤外科,湖南衡阳421001 [2]湘南学院临床医学系,湖南郴州423000

出　　处：《湘南学院学报（医学版）》2012年第3期34-36,共3页Journal of Xiangnan University（Medical Sciences）

基　　金：湖南省教育厅科学研究项目;湘南学院科研项目(08Y033)

摘　　要：目的研究人子宫内膜癌组织中是否存在血管生成拟态(VM)及其临床意义。方法收集子宫内膜癌标本60例及临床病理资料,CD34-PAS双重染色证实VM存在,分析VM与患者临床病理指标之间的关系。结果 13例标本中存在VM。低分化子宫内膜癌中VM出现的机率高于高分化子宫内膜癌(P=0.001)。VM组的手术病理分期比无VM组高(P=0.013)。VM组有更高的转移率(P=0.003)。结论子宫内膜癌组中存在VM,是高度恶性生物学行为的基础之一。Objective To study vasculogenic mimicry（VM） and its clinical significance in endometrial carcin noma. Methods Specimens of 87 cases were collected along with their clinicopathologic data. VM channels were detected using CD34/PAS double staining and were then used to study the correlation between VM and clinico pathologic factors. Results 13 cases have VM of the all 60 patients （positive rate 21.7 % ）. The positive rate of VM in poorly differentiated endometrial carcinnoma was significantly higher than that in well differentiated endometrial carcinnoma（ P = 0.001）. FIGO sgate of the VM group was more advanced than that the non VM group（ P = 0.013）, and the VM group had a higher rate of occurrence of hematogenous metastases（ P = 0.003）. Conclu sion Vasculogenic mimicry exist in endometrial carcinnoma. This is one basis of biological behavior in high malig nant.

关 键 词：血管生成拟态 子宫内膜癌 CD34-PAS双重染色 

分 类 号：R737.33[医药卫生—肿瘤]