异甘草酸镁对酒精性肝炎的疗效观察  

Effect of magnesium isoglycyrrhizinate in treatment of alcoholic hepatitis

作　　者：吴况明[1] 何蔡为[1] 

机构地区：[1]湖南省益阳市中心医院消化内科,413000

出　　处：《中国医药》2012年第10期1263-1264,共2页China Medicine

摘　　要：目的观察异甘草酸镁对于酒精性肝炎的疗效。方法选择益阳市中心医院2006年3月至2012年3月期间收治的酒精性肝炎患者80例，完全随机分为研究组（40例）和对照组（40例），研究组给予异甘草酸镁注射液150mg溶于10％葡萄糖溶液250ml，1次／d静脉滴注，同时应用多烯磷脂酰胆碱10ml溶于10％葡萄糖溶液250ml，1次／d静脉滴注。对照组予以还原型谷胱甘肽1．8g溶于10％葡萄糖溶液250ml，17次／d静脉滴注，同时应用多烯磷脂酰胆碱10ml溶于10％葡萄糖溶液250ml，1次／d静脉滴注，治疗时间2-3周。结果研究组乏力、纳差、腹胀、黄疸、肝脏肿大和压痛减轻率均高于对照组（均P〈0．05）。研究组治疗后ALT、AST、γ-谷氨酰转肽酶、总胆红素的水平均低于对照组（P〈0．05）。研究组治疗总有效率明显高于对照组[87．5％（35／40）比70．0％（28／40）]，差异有统计学意义（P〈0．05）。结论异甘草酸镁对于控制酒精性肝炎炎症活动有显著作用，且优于还原型谷胱甘肽。Objective To investigate the effect of magnesium isoglycyrrhizinate in treatment of alcoholic hepatitis. Methods Eighty patients were randomly divided into treatment group （ n = 40 ） and controi group （ n = 40）. Patients in the treatment group were given magnesium isoglycyrrhizinate 150 mg and polyene phosphatidylcholine 10 ml once everyday. Patients in the control group were given reduced glutathione 1.8 g and polyene phosphatidylcholine 10 ml once everyday. The Course was 2-3 weeks. Changes of clinical manifestations, biochemical and immunological indexes were observed. Results Patients in both groups showed therapeutic effect with statistical significance （P 〈 0. 05 ）. After treatment, the degree of biochemieal indicators declined significantly in the treatment group than that of the control group （ P 〈 0. 05 ）. The total effective rate of the treatment group was significantly higher than that of control group [87.5% （35/40） vs 70.0% （28/40） ]. Conclusion The result shows that magnesium isoglycyrrhizinate and reduced glutathione are effective drugs for controlling inflammation activity of the alcoholic hepatitis and magnesium isoglycyrrhizinate is a more effective and safer agent than reduced glutathione.

关 键 词：酒精性肝炎 异甘草酸镁 还原型谷胱甘肽 

分 类 号：R575.1[医药卫生—消化系统]