应用纤维蛋白胶和医用OB胶修复兔面神经损伤的实验研究  

An experimental study of facial nerve repair by using fibrin glue or OB glue

作　　者：徐勤业[1] 屈振宇 蒋红卫[1] 曲卫国 马卫东 张刘超 

机构地区：[1]浙江省义乌市中心医院口腔科,322000 [2]大连市口腔医院口腔颌面外科

出　　处：《实用口腔医学杂志》2012年第5期554-557,共4页Journal of Practical Stomatology

基　　金：大连市优秀青年科技人才基金(编号:2006J23JH016)

摘　　要：目的:探讨用纤维蛋白胶或医用OB胶修复兔面神经的损伤效果。方法:手术制作实验用健康30只新西兰大耳白兔右侧面神经下颊支损伤模型,随机分成3组,分别为显微外科吻合组(Ⅰ组)、纤维蛋白胶粘合组(Ⅱ组)、医用OB胶粘合组(Ⅲ组),分别进行修复。术后16周进行大体观察、神经电生理检测、组织学观察、图像分析,评价神经再生恢复情况。结果:16周时肉眼观察3个组吻合口处均见神经再生,可抵抗一定拉力,Ⅰ组和Ⅲ组修复神经的周围软组织粘连较Ⅱ组严重;与Ⅰ组相比,Ⅱ组轴突再生率和再生轴突恢复比均有提高。结论:纤维蛋白胶和医用OB胶均有较好的生物相容性,可修复神经损伤,纤维蛋白胶对神经损伤的修复效果更佳。Objective： To study the effects of fibrin glue and OB glue in the treatment of rabbit facial nerve injury. Methods： The nerve disjunction model was made in right facial nerve in 30 New Zeland rabbits. Then the animals were treated by nerve autografts （ group Ⅰ）, Fibrin glue（ group Ⅱ ） and OB glue （ group Ⅲ） （ n = 10 ） respectively. General observation, electrophysiological study, histological study and image analysis were performed 16 weeks after treatment. Results： Nerve regeneration was observed in the 3 groups 16 weeks after treatment and the treated nerves could resist a certain tension. The tissue adhesion in group Ⅰ and group Ⅲ were more severe than in group Ⅱ. The rate of regeneration of myelinated axon and the recovery ratio of myelinated fiber was higher in group Ⅱ than in group Ⅲ. Conclusion： Both fibrin glue and OB glue are effective in repairing nerve disjunction. The fibrin glue is more effective.

关 键 词：纤维蛋白胶 医用OB胶 氰基丙烯酸酯胶 周围神经 

分 类 号：R745.12[医药卫生—神经病学与精神病学]