兼具微米-纳米钛表面的生物力学研究  

Biomechanic study on the hierarchical micro-nano titanium surface

作　　者：孟维艳[1] 周延民[1] 张艳靖[2] 蔡青[1] 杨立明[1] 

机构地区：[1]吉林大学口腔医院种植科,长春130021 [2]郑州大学第四附属医院种植科

出　　处：《实用口腔医学杂志》2012年第5期558-562,共5页Journal of Practical Stomatology

基　　金：吉林省科技厅白求恩专项基金(编号:200905175)

摘　　要：目的:通过拔出力试验研究兼具微米-纳米纯钛表面对骨整合速度的影响。方法:采用电化学处理的方法(EE组)在纯钛表面产生兼具微米-纳米的微结构,将电化学表面处理试件植入日本大耳白兔右侧胫骨中,以喷砂加酸蚀组(SLA组)、机械加工组(M组)为对照组。种植术后4周、7周、10周、13周后,用万能材料试验机将试件从骨内拉出,分别测定各个周期的拔出力。结果:4周、7周、10周、13周时,EE、SLA和M组试件的拔出力存在差异,其中EE组高于SLA组和M组(P<0.05)。结论:兼具微米-纳米的电化学表面处理可明显提高骨-种植体界面的愈合速度。Objective： To study the effect of the titanium surface with hierarchical micro-nano topography on the osseointegration. Methods： The hierarchical micro-nano topography was produced on titanium surface by electrochemical （EE） method. The specimens with EE surface were implanted into the right tibia of Japanese white rabbits. The specimens with grit-blasted/acid-treated surface （SLA） and michanicaly treated（M） surface were respectively used in control groups. The pull-out force of the specimens was measured by universal material testing machine 4,7,10 and 13 weeks after the surgery. Results： 4,7,10 and 13 weeks after implantation, the pull-out force was different among three groups. In EE group the pull-out force was significantly higher than that in SLA and M groups （P 〈 0.05）. Conclusion： EE surface with the hierarchical micro-nano topography of titanium can promote bone formation and shorten the implant-bone healing time.

关 键 词：种植体 微米形貌 纳米形貌 骨整合 

分 类 号：R783.6[医药卫生—口腔医学]